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0KLHL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKLHL2
DescriptionKelch-like protein 2 (actin-binding protein mayven).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015629 actin cytoskeleton (TAS)
0005215 transporter activity (TAS)
0006886 intracellular protein transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found associated with and .
  IPR011705:BTB/Kelch-associated
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
Kelch is a 50-residue motif.amed after the Drosophila mutant in which it was first identified . The motif appears 6 times in Drosophila egg-chamber regulatory protein.nd is also found in mouse protein MIPP and in a number of poxviruses. In addition.elch repeats have been recognised in alpha- and beta-scruin and in galactose oxidase from the fungus Dactylium dendroides . The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold .The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function.s it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila . Nevertheless.ased on the location of the kelch pattern in the catalytic unit in galactose oxidase.unctionally important residues have been predicted in glyoxal oxidase .
  IPR006652:Kelch repeat
Kelch is a 50-residue motif.amed after the Drosophila mutant in which it was first identified . The motif appears 6 times in Drosophila egg-chamber regulatory protein.nd is also found in mouse protein MIPP and in a number of poxviruses. In addition.elch repeats have been recognised in alpha- and beta-scruin and in galactose oxidase from the fungus Dactylium dendroides . The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold .The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function.s it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila . Nevertheless.ased on the location of the kelch pattern in the catalytic unit in galactose oxidase.unctionally important residues have been predicted in glyoxal oxidase .
  IPR006651:Kelch motif
Galactose oxidase () is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde . The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation . Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich.he central domain forms a seven 4-bladed beta-propeller.nd the C-terminal domain has an immunoglobulin-like fold.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011043:Galactose oxidase, central
IPR011705:BACK 
Evalue:-53.1870880126953 
Location:158-260IPR013069:BTB 
Evalue:-40.236572265625 
Location:46-153IPR006652:Kelch_1 
Evalue:-17.7212467193604 
Location:485-530IPR006652:Kelch_1 
Evalue:-17.6197891235352 
Location:436-483IPR006652:Kelch_1 
Evalue:-16.5228786468506 
Location:389-434IPR006652:Kelch_1 
Evalue:-16.3372421264648 
Location:532-577IPR006652:Kelch_1 
Evalue:-15 
Location:342-387IPR006652:Kelch_1 
Evalue:-5.53760194778442 
Location:308-340
SequencesProtein: KLHL2_HUMAN (593 aa)
mRNA: NM_007246
Local Annotation
Synapse Ontology
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 89 residues, 166348240-166348504Exon2: 44 residues, 166360535-166360661Exon3: 37 residues, 166369408-166369515Exon4: 42 residues, 166379379-166379501Exon5: 56 residues, 166403798-166403961Exon6: 38 residues, 166434960-166435070Exon7: 41 residues, 166438210-166438327Exon8: 52 residues, 166440108-166440258Exon9: 41 residues, 166446209-166446327Exon10: 68 residues, 166451154-166451352Exon11: 36 residues, 166452065-166452167Exon12: 45 residues, 166453839-166453968Exon13: 49 residues, 166454627-166454768Exon14: 50 residues, 166458427-166458571Exon15: 373 residues, 166462633-166463748Exon16: 2 residues, -Jump to KLHL2_HUMAN  
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