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0KLF12_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKLF12
DescriptionKrueppel-like factor 12 (transcriptional repressor ap-2rep).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003714 transcription corepressor activity (TAS)
0003700 transcription factor activity (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Zinc finger domains .re nucleic acid-binding protein structures first identified in the Xenopus laevis transcription factor TFIIIA. These domains have since been found in numerous nucleic acid-binding proteins. A zinc finger domain is composed of 25 to 30 amino-acid residues including 2 conserved Cys and 2 conserved His residues in a C-2-C-12-H-3-H type motif. The 12 residues separating the second Cys and the first His are mainly polar and basic.mplicating this region in particular in nucleic acid binding. The zinc finger motif is an unusually small.elf-folding domain in which Zn is a crucial component of its tertiary structure. All bind 1 atom of Zn in a tetrahedral array to yield a finger-like projection.hich interacts with nucleotides in the major groove of the nucleic acid. The Zn binds to the conserved Cys and His residues. Fingers have been found to bind to about 5 base pairs of nucleic acid containing short runs of guanine residues. They have the ability to bind to both RNA and DNA.nd it has been suggested that the zinc finger may thus represent the original nucleic acid binding protein. It has also been suggested that a Zn-centred domain could be used in a protein interaction..g. in protein kinase C. Many classes of zinc fingers are characterized according to the number and positions of the histidine and cysteine residues involved in the zinc atom coordination. In the first class to be characterized.alled C2H2.he first pair of zinc coordinating residues are cysteines.hile the second pair are histidines.
  IPR007087:Zinc finger, C2H2-type
IPR007087:zf-C2H2 
Evalue:-5.85387182235718 
Location:347-371IPR007087:zf-C2H2 
Evalue:-5.82390880584717 
Location:377-399IPR007087:zf-C2H2 
Evalue:-5.19381999969482 
Location:317-341
SequencesProtein: KLF12_HUMAN (402 aa)
mRNA: NM_007249
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 3220 residues, 73158150-73167809Exon2: 54 residues, 73187505-73187663Exon3: 23 residues, 73237075-73237138Exon4: 47 residues, 73285289-73285425Exon5: 184 residues, 73317964-73318511Exon6: 32 residues, 73416118-73416208Exon7: 23 residues, 73467127-73467191Exon8: 57 residues, 73605876-73606043Exon9: 2 residues, -Jump to KLF12_HUMAN  
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