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0KKCC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCAMKK1
DescriptionCalcium/calmodulin-dependent protein kinase kinase 1 (ec 2.7.1.37) (calcium/calmodulin-dependent protein kinase kinase alpha) (cam-kinase kinase alpha) (cam-kk alpha) (camkk alpha) (camkk 1) (cam-kinase iv kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-93.602059991328 
Location:128-409
SequencesProtein: KKCC1_HUMAN (505 aa)
mRNA: NM_032294
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK07359
  Level 3 annotation:
    calcium/calmodulin-dependent protein kinase kinase
  Level 2 annotation:
    Adipocytokine signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 652 residues, 3710373-3712326Exon2: 36 residues, 3715950-3716054Exon3: 45 residues, 3719529-3719658Exon4: 31 residues, 3719843-3719931Exon5: 26 residues, 3722596-3722670Exon6: 20 residues, 3723451-3723505Exon7: 68 residues, 3726265-3726465Exon8: 31 residues, 3730388-3730477Exon9: 9 residues, 3731669-3731691Exon10: 14 residues, 3732570-3732607Exon11: 46 residues, 3733084-3733218Exon12: 19 residues, 3733471-3733523Exon13: 20 residues, 3733926-3733980Exon14: 18 residues, 3734422-3734470Exon15: 136 residues, 3735370-3735773Exon16: 37 residues, 3742981-3743086Exon17: 2 residues, -Jump to KKCC1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4249 2912712-2913651 ~-1K 14853(OR1D5)(-)Loci: 4250 2976653-2977595 ~-1K 14854(OR1G1)(-)Loci: 4251 3127934-3129018 ~-1K 14856(OR3A2)(-)Loci: 2967 3270617-3271577 ~-1K 14858(OR3A3)(+)Loci: 2968 3486764-3511581 ~-25K 14869(CTNS)(+)Loci: 2969 3573945-3576739 ~-3K 14877(GSG2)(+)Loci: 4252 3710373-3743086 ~-33K 14879(CAMKK1)(-)Loci: 4253 3773917-3814485 ~-41K 14884(ATP2A3)(-)Loci: 4254 4013949-4114000 ~-100K 14897(ANKFY1)(-)Loci: 2966 2443685-2535638 ~-92K 14848(PAFAH1B1)(+)Link out to UCSC