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0KITM_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTK2
DescriptionThymidine kinase 2, mitochondrial precursor (ec 2.7.1.21) (mt-tk).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004797 thymidine kinase activity (TAS)
0006139 nucleobase, nucleoside, nucleotide and nucl... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of various deoxynucleoside kinases including cytidine ().uanosine ().denosine () and thymidine kinase (.hich also phosphorylates deoxyuridine and deoxycytosine. These enzymes catalyse the production of deoxynucleotide 5-monophosphate from a deoxynucleoside.sing ATP and yielding ADP in the process.
  IPR002624:Deoxynucleoside kinase
IPR002624:dNK 
Evalue:-64.0861892700195 
Location:113-257
SequencesProtein: KITM_HUMAN (266 aa)
mRNA: NM_004614 Y10498
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00857
  Level 3 annotation:
    thymidine kinase
  Level 2 annotation:
    Pyrimidine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 441 residues, 65102150-65103470Exon2: 29 residues, 65105134-65105215Exon3: 28 residues, 65108539-65108619Exon4: 31 residues, 65109192-65109281Exon5: 26 residues, 65120397-65120471Exon6: 32 residues, 65122783-65122873Exon7: 20 residues, 65128367-65128421Exon8: 27 residues, 65133282-65133357Exon9: 12 residues, 65140381-65140413Exon10: 82 residues, 65141341-65141581Exon11: 2 residues, -Jump to KITM_HUMANExon1: 441 residues, 65102150-65103470Exon2: 29 residues, 65105134-65105215Exon3: 28 residues, 65108539-65108619Exon4: 31 residues, 65109192-65109281Exon5: 26 residues, 65120397-65120471Exon6: 32 residues, 65122783-65122873Exon7: 20 residues, 65128367-65128421Exon8: 27 residues, 65133282-65133357Exon9: 12 residues, 65140381-65140413Exon10: 160 residues, 65141341-65141816Exon11: 2 residues, -Jump to KITM_HUMAN  
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Loci Cluster (Details)Loci: 2945 65471936-65479356 ~-7K 14263(PDP2)(+)Loci: 4230 65513089-65516920 ~-4K 14266(RRAD)(-)Loci: 4231 65767007-65774977 ~-8K 14287(-)Loci: 2946 66153964-66230588 ~-77K 14315(CTCF)(+)Loci: 2947 66252351-66254181 ~-2K 14321(PARD6A)(+)Loci: 4232 66531287-66535516 ~-4K 14345(LCAT)(-)Loci: 4233 66535730-66560026 ~-24K 14346(SLC12A4)(-)Loci: 4229 65102150-65141816 ~-40K 14239(TK2)(-)Link out to UCSC