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0KISSR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGPR54
DescriptionKiss-1 receptor (kiss-1r) (kisspeptins receptor) (metastin receptor) (g-protein coupled receptor 54) (hypogonadotropin-1) (hot7t175).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (IEP)
0008188 neuropeptide receptor activity (IDA)
0005515 protein binding (IPI)
0007610 behavior (NAS)
0007186 G-protein coupled receptor protein signalin... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .The metastasis suppressor gene KiSS-1 encodes a number of RFamide-related peptides.he largest of which.etastin.ontains 54 amino acids.An orphan G protein-coupled receptor.PR54.as been identified as a receptor for these peptides . GPR54 is highly expressed in placenta.ituitary.ancreas and spinal cord. Binding of KiSS-1-encoded peptidesto the receptor results in coupling to the Gq pathway.timulating calciummobilisation.hosphatidylinositol hydrolysis.rachidonic acid release.RK and p38 MAP kinase phosphorylation and stress fibre formation. It alsoinhibits cell proliferation. The distribution of GPR54.ogether with the finding that administration of KiSS-1 peptides in rat stimulates oxytocin secretion.uggests a role in regulation of endocrine function.
  IPR008103:KiSS-1 peptide receptor
IPR000276:7tm_1 
Evalue:-63.9586067199707 
Location:59-323IPR008103:KISS1RECEPTR 
Evalue:0 
Location:5-24IPR008103:KISS1RECEPTR 
Evalue:0 
Location:25-43IPR008103:KISS1RECEPTR 
Evalue:0 
Location:327-340IPR000276:G_PROTEIN_RECEP_F1_1 
Evalue:0 
Location:0-0
SequencesProtein: KISSR_HUMAN (398 aa)
mRNA: NM_032551
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 130 residues, 868357-868746Exon2: 43 residues, 869543-869668Exon3: 47 residues, 870489-870625Exon4: 79 residues, 870873-871106Exon5: 243 residues, 871289-872013Exon6: 2 residues, -Jump to KISSR_HUMAN  
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Loci Cluster (Details)Loci: 4349 568224-584530 ~-16K 17494(POLRMT)(-)Loci: 3077 868357-872013 ~-4K 17519(GPR54)(+)Loci: 3078 951436-960723 ~-9K 17523(GRIN3B)(+)Loci: 3079 1192748-1195823 ~-3K 17537(ATP5D)(+)Loci: 3080 1334888-1346583 ~-12K 17550(+)Loci: 4350 1766247-1799450 ~-33K 17579(-)Loci: 4351 1988469-2002233 ~-14K 17594(MKNK2)(-)Loci: 4352 2051987-2102554 ~-51K 17601(AP3D1)(-)Loci: 3076 540892-568157 ~-27K 17493(HCN2)(+)Link out to UCSC