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0KIFA3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionKinesin-associated protein 3 (smg gds-associated protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0016939 kinesin II complex (ISS)
0005515 protein binding (IPI)
0007017 microtubule-based process (ISS)
0006461 protein complex assembly (TAS)
0007165 signal transduction (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein.orming a heterotrimeric complex in vitro.alled the Kinesin-II .
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes.ncluding intracellular signalling and cytoskeletal regulation.nd include such proteins as beta-catenin.he junctional plaque protein plakoglobin.he adenomatous polyposis coli (APC) tumour suppressor protein.nd the nuclear transport factor importin-alpha.mongst others . A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants.ome Arm-repeat proteins function in intracellular signalling like their mammalian counterparts.hile others have novel functions .The 3-dimensional fold of an armadillo repeat is known from the crystal structure of the 12 repeats form a superhelix of alpha helices with three helices per unit . The cylindrical structure features a positively charged grove.hich presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
SequencesProtein: KIFA3_HUMAN (792 aa)
mRNA: NM_014970
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 151 residues, 168157094-168157546Exon2: 35 residues, 168189775-168189875Exon3: 65 residues, 168196810-168197000Exon4: 30 residues, 168208277-168208363Exon5: 35 residues, 168213849-168213948Exon6: 44 residues, 168217736-168217862Exon7: 57 residues, 168218466-168218632Exon8: 39 residues, 168219034-168219147Exon9: 38 residues, 168220346-168220455Exon10: 35 residues, 168227919-168228020Exon11: 56 residues, 168252226-168252389Exon12: 61 residues, 168260182-168260361Exon13: 35 residues, 168267650-168267749Exon14: 43 residues, 168270136-168270261Exon15: 35 residues, 168271218-168271318Exon16: 49 residues, 168274054-168274196Exon17: 20 residues, 168274997-168275053Exon18: 53 residues, 168282476-168282631Exon19: 46 residues, 168291069-168291201Exon20: 103 residues, 168310200-168310503Exon21: 2 residues, -Jump to KIFA3_HUMAN  
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