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0KIF5C_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionKinesin heavy chain isoform 5c (kinesin heavy chain neuron-specific 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005871 kinesin complex (TAS)
0003777 microtubule motor activity (TAS)
0006996 organelle organization and biogenesis (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin motor activity is directed toward the microtubules plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.The heavy chain is composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it is known to hydrolyze ATP.o bind and move on microtubules). central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains).esicles and membranous organelles.A number of proteins have been recently found that contain a domain similar to that of the kinesin motor domain .Drosophila melanogaster claret segregational protein (ncd). Ncd is required for normal chromosomal segregation in meiosis.n females.nd in early mitotic divisions of the embryo. The ncd motor activity is directed toward the microtubules minus end.Homo sapiens CENP-E . CENP-E is a protein that associates with kinetochores during chromosome congression.elocates to the spindle midzone at anaphase.nd is quantitatively discarded at the end of the cell division. CENP-E is probably an important motor molecule in chromosome movement and/or spindle elongation.H.sapiens mitotic kinesin-like protein-1 (MKLP-1). motor protein whose activity is directed toward the microtubules plus end.Saccharomyces cerevisiae KAR3 protein.hich is essential for S. cerevisiae nuclear fusion during mating. KAR3 may mediate microtubule sliding during nuclear fusion and possibly mitosis.S. cerevisiae CIN8 and KIP1 proteins which are required for the assembly of the mitotic spindle. Both proteins seem to interact with spindle microtubules to produce an outwardly directed force acting upon the poles.Emericella nidulans bimC.hich plays an important role in nuclear division.E. nidulans klpA.Caenorhabditis elegans unc-104.hich may be required for the transport of substances needed for neuronal cell differentiation.C. elegans osm-3.Xenopus laevis Eg5.hich may be involved in mitosis.Arabidopsis thaliana KatA.atB and katC.Chlamydomonas reinhardtii FLA10/KHP1 and KLP1. Both proteins seem to play a role in the rotation or twisting of the microtubules of the flagella.C. elegans hypothetical protein T09A5.2.The kinesin motor domain is located in the N-terminal part of most of the above proteins.ith the exception of KAR3.lpA.nd ncd where it is located in the C-terminal section.The kinesin motor domain contains about 330 amino acids. An ATP-binding motif of type A is found near position 80 to 90.he C-terminal half of the domain is involved in microtubule-binding.
  IPR001752:Kinesin, motor region
SequencesProtein: KIF5C_HUMAN (957 aa)
mRNA: AB011103
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 165 residues, 149349288-149349782Exon2: 32 residues, 149396175-149396266Exon3: 37 residues, 149502041-149502148Exon4: 18 residues, 149506369-149506418Exon5: 20 residues, 149506694-149506750Exon6: 31 residues, 149507432-149507520Exon7: 43 residues, 149511658-149511783Exon8: 37 residues, 149514598-149514703Exon9: 51 residues, 149515073-149515222Exon10: 51 residues, 149526730-149526879Exon11: 60 residues, 149538095-149538271Exon12: 25 residues, 149543681-149543750Exon13: 71 residues, 149546114-149546321Exon14: 51 residues, 149548379-149548526Exon15: 65 residues, 149555769-149555958Exon16: 41 residues, 149559180-149559298Exon17: 27 residues, 149562023-149562100Exon18: 38 residues, 149563159-149563269Exon19: 36 residues, 149565182-149565284Exon20: 22 residues, 149565481-149565542Exon21: 26 residues, 149570152-149570224Exon22: 37 residues, 149572722-149572827Exon23: 74 residues, 149574894-149575111Exon24: 40 residues, 149576329-149576443Exon25: 1229 residues, 149587837-149591519Exon26: 2 residues, -Jump to KIF5C_HUMAN  
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Loci Cluster (Details)Loci: 3189 149349288-149591519 ~-242K 21384(KIF5C)(+)Loci: 3188 149119037-149261600 ~-143K 21380(+)Link out to UCSC