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0KIF22_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKIF22
DescriptionKinesin-like protein kif22 (kinesin-like dna-binding protein) (kinesin-like protein 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0000776 kinetochore (TAS)
0005634 nucleus (TAS)
0003677 DNA binding (TAS)
0003777 microtubule motor activity (TAS)
0007067 mitosis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The HhH motif is an around 20 amino acids domain present in prokaryotic andeukaryotic non-sequence-specific DNA binding proteins . The HhH motif is similar to.ut distinct from.he HtH motif. Both of thesemotifs have two helices connected by a short turn. In the HtH motif the secondhelix binds to DNA with the helix in the major groove. This allow the contactbetween specific base and residues throughout the protein. In the HhH motifthe second helix does not protrude from the surface of the protein andtherefore cannot lie in the major groove of the DNA. Crystallographic studiessuggest that the interaction of the HhH domain with DNA is mediated by aminoacids located in the strongly conserved loop (L-P-G-V) and at the N-terminalend of the second helix . This interaction could involve the formation ofhydrogen bonds between protein backbone nitrogens and DNA phosphate groups. The structural difference between the HtH and HhH domains is reflected at thefunctional level: whereas the HtH domain.ound primarily in gene regulatoryproteins.inds DNA in a sequence specific manner.he HhH domain is ratherfound in proteins involved in enzymatic activities and binds DNA with nosequence specificity .
  IPR003583:Helix-hairpin-helix DNA-binding, class 1
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin motor activity is directed toward the microtubules plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.The heavy chain is composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it is known to hydrolyze ATP.o bind and move on microtubules). central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains).esicles and membranous organelles.A number of proteins have been recently found that contain a domain similar to that of the kinesin motor domain .Drosophila melanogaster claret segregational protein (ncd). Ncd is required for normal chromosomal segregation in meiosis.n females.nd in early mitotic divisions of the embryo. The ncd motor activity is directed toward the microtubules minus end.Homo sapiens CENP-E . CENP-E is a protein that associates with kinetochores during chromosome congression.elocates to the spindle midzone at anaphase.nd is quantitatively discarded at the end of the cell division. CENP-E is probably an important motor molecule in chromosome movement and/or spindle elongation.H.sapiens mitotic kinesin-like protein-1 (MKLP-1). motor protein whose activity is directed toward the microtubules plus end.Saccharomyces cerevisiae KAR3 protein.hich is essential for S. cerevisiae nuclear fusion during mating. KAR3 may mediate microtubule sliding during nuclear fusion and possibly mitosis.S. cerevisiae CIN8 and KIP1 proteins which are required for the assembly of the mitotic spindle. Both proteins seem to interact with spindle microtubules to produce an outwardly directed force acting upon the poles.Emericella nidulans bimC.hich plays an important role in nuclear division.E. nidulans klpA.Caenorhabditis elegans unc-104.hich may be required for the transport of substances needed for neuronal cell differentiation.C. elegans osm-3.Xenopus laevis Eg5.hich may be involved in mitosis.Arabidopsis thaliana KatA.atB and katC.Chlamydomonas reinhardtii FLA10/KHP1 and KLP1. Both proteins seem to play a role in the rotation or twisting of the microtubules of the flagella.C. elegans hypothetical protein T09A5.2.The kinesin motor domain is located in the N-terminal part of most of the above proteins.ith the exception of KAR3.lpA.nd ncd where it is located in the C-terminal section.The kinesin motor domain contains about 330 amino acids. An ATP-binding motif of type A is found near position 80 to 90.he C-terminal half of the domain is involved in microtubule-binding.
  IPR001752:Kinesin, motor region
In prokaryotes.uvA.uvB.nd RuvC process the universal DNA intermediate of homologous recombination.ermed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure . In the RuvA tetramer.ach subunit consists of three domains..I and III.here I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point.hereas domain III regulates branch migration through direct contact with RuvB. Domain 2 has a SAM (sterile alpha motif)-like alpha bundle fold that occurs as a duplication containing two helix-hairpin-helix (HhH) motifs.The C-terminal domain (CTD) of the excision repair protein UvrC shows structural similarity to RuvA domain 2. The CTD of UvrC is essential for 5 incision in the prokaryotic nucleotide excision repair process.nd acts to mediate structure-specific binding to single-stranded-double-stranded junction DNA .Domain 3 of NAD+-dependent DNA ligase consists of a duplication of two RuvA-like domains (four HhH motifs).nd also contains a zinc-finger subdomain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication.epair and recombination.tilizing either ATP or NAD+ as a cofactor .
  IPR010994:RuvA domain 2-like
IPR001752:KISc 
Evalue:-142.0268721464 
Location:41-376IPR003583:HhH1 
Evalue:-0.267606240177031 
Location:602-621IPR003583:HhH1 
Evalue:1.72427586960079 
Location:632-651
SequencesProtein: KIF22_HUMAN (665 aa)
mRNA: BC004352
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 30 residues, 29709562-29709651Exon2: 67 residues, 29715714-29715910Exon3: 44 residues, 29717195-29717323Exon4: 53 residues, 29717414-29717569Exon5: 72 residues, 29717796-29718006Exon6: 79 residues, 29718085-29718316Exon7: 53 residues, 29718449-29718603Exon8: 47 residues, 29718734-29718870Exon9: 58 residues, 29721590-29721759Exon10: 55 residues, 29722270-29722430Exon11: 24 residues, 29722819-29722887Exon12: 73 residues, 29723635-29723848Exon13: 22 residues, 29723936-29723996Exon14: 42 residues, 29724084-29724205Exon15: 2 residues, -Jump to KIF22_HUMAN  
Loci Cluster (Details)Loci: 2933 29709562-29724205 ~-15K 13857(KIF22)(+)Loci: 4218 29924337-29929902 ~-6K 13883(DOC2A)(-)Loci: 2934 29971991-29989235 ~-17K 13889(ALDOA)(+)Loci: 2935 30102426-30107897 ~-5K 13900(CORO1A)(+)Loci: 2936 30113969-30123150 ~-9K 13906(SULT1A3)(+)Loci: 2932 29374627-29383801 ~-9K 13851(SULT1A3)(+)Link out to UCSC