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0KI21A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKIF21A
DescriptionKinesin family member 21a (kinesin-like protein kif2) (ny-ren-62 antigen).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The kinesin motor activity is directed toward the microtubules plus end. Kinesin is an oligomeric complex composed of two heavy chains and two light chains. The maintenance of the quaternary structure does not require interchain disulphide bonds.The heavy chain is composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it is known to hydrolyze ATP.o bind and move on microtubules). central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains).esicles and membranous organelles.A number of proteins have been recently found that contain a domain similar to that of the kinesin motor domain .Drosophila melanogaster claret segregational protein (ncd). Ncd is required for normal chromosomal segregation in meiosis.n females.nd in early mitotic divisions of the embryo. The ncd motor activity is directed toward the microtubules minus end.Homo sapiens CENP-E . CENP-E is a protein that associates with kinetochores during chromosome congression.elocates to the spindle midzone at anaphase.nd is quantitatively discarded at the end of the cell division. CENP-E is probably an important motor molecule in chromosome movement and/or spindle elongation.H.sapiens mitotic kinesin-like protein-1 (MKLP-1). motor protein whose activity is directed toward the microtubules plus end.Saccharomyces cerevisiae KAR3 protein.hich is essential for S. cerevisiae nuclear fusion during mating. KAR3 may mediate microtubule sliding during nuclear fusion and possibly mitosis.S. cerevisiae CIN8 and KIP1 proteins which are required for the assembly of the mitotic spindle. Both proteins seem to interact with spindle microtubules to produce an outwardly directed force acting upon the poles.Emericella nidulans bimC.hich plays an important role in nuclear division.E. nidulans klpA.Caenorhabditis elegans unc-104.hich may be required for the transport of substances needed for neuronal cell differentiation.C. elegans osm-3.Xenopus laevis Eg5.hich may be involved in mitosis.Arabidopsis thaliana KatA.atB and katC.Chlamydomonas reinhardtii FLA10/KHP1 and KLP1. Both proteins seem to play a role in the rotation or twisting of the microtubules of the flagella.C. elegans hypothetical protein T09A5.2.The kinesin motor domain is located in the N-terminal part of most of the above proteins.ith the exception of KAR3.lpA.nd ncd where it is located in the C-terminal section.The kinesin motor domain contains about 330 amino acids. An ATP-binding motif of type A is found near position 80 to 90.he C-terminal half of the domain is involved in microtubule-binding.
  IPR001752:Kinesin, motor region
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR001752:Kinesin 
Evalue:-167.251815795898 
Location:15-372IPR001680:WD40 
Evalue:-7.76955127716064 
Location:1337-1373IPR001680:WD40 
Evalue:-6.92081880569458 
Location:1616-1652IPR001680:WD40 
Evalue:-5.16115093231201 
Location:1482-1523IPR001680:WD40 
Evalue:-4.65757751464844 
Location:1574-1612IPR001680:WD40 
Evalue:-3.79588007926941 
Location:1377-1414IPR001680:WD40 
Evalue:-2.27572417259216 
Location:1441-1478IPR001680:WD40 
Evalue:-2.14266753196716 
Location:1532-1569IPR011046:WD40_like 
Evalue:0 
Location:4-9
SequencesProtein: KI21A_HUMAN (1674 aa)
mRNA: AY368076 NM_017641
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 430 residues, 37973297-37974586Exon2: 68 residues, 37981548-37981748Exon3: 59 residues, 37983033-37983204Exon4: 41 residues, 37984889-37985007Exon5: 57 residues, 37987633-37987798Exon6: 62 residues, 37989654-37989835Exon7: 47 residues, 37991485-37991622Exon8: 6 residues, 37995297-37995309Exon9: 15 residues, 37996000-37996039Exon10: 45 residues, 37998141-37998270Exon11: 38 residues, 37999974-38000082Exon12: 73 residues, 38002736-38002951Exon13: 20 residues, 38005907-38005962Exon14: 22 residues, 38006332-38006393Exon15: 9 residues, 38010310-38010331Exon16: 57 residues, 38010814-38010980Exon17: 36 residues, 38011758-38011860Exon18: 67 residues, 38012282-38012477Exon19: 53 residues, 38012659-38012813Exon20: 73 residues, 38012961-38013176Exon21: 25 residues, 38013280-38013349Exon22: 38 residues, 38017164-38017272Exon23: 68 residues, 38020233-38020433Exon24: 65 residues, 38020974-38021163Exon25: 41 residues, 38021573-38021691Exon26: 32 residues, 38022102-38022193Exon27: 70 residues, 38031845-38032049Exon28: 23 residues, 38036900-38036964Exon29: 65 residues, 38037316-38037506Exon30: 67 residues, 38038246-38038442Exon31: 40 residues, 38043166-38043282Exon32: 58 residues, 38046418-38046586Exon33: 47 residues, 38047098-38047233Exon34: 52 residues, 38047951-38048101Exon35: 63 residues, 38049797-38049980Exon36: 76 residues, 38050107-38050330Exon37: 65 residues, 38122995-38123185Exon38: 2 residues, -Jump to KI21A_HUMANExon1: 33 residues, 37974490-37974586Exon2: 68 residues, 37981548-37981748Exon3: 59 residues, 37983033-37983204Exon4: 41 residues, 37984889-37985007Exon5: 57 residues, 37987633-37987798Exon6: 62 residues, 37989654-37989835Exon7: 47 residues, 37991485-37991622Exon8: 6 residues, 37995297-37995309Exon9: 15 residues, 37996000-37996039Exon10: 45 residues, 37998141-37998270Exon11: 38 residues, 37999974-38000082Exon12: 73 residues, 38002736-38002951Exon13: 20 residues, 38005907-38005962Exon14: 22 residues, 38006332-38006393Exon15: 9 residues, 38010310-38010331Exon16: 57 residues, 38010814-38010980Exon17: 36 residues, 38011758-38011860Exon18: 67 residues, 38012282-38012477Exon19: 53 residues, 38012659-38012813Exon20: 73 residues, 38012961-38013176Exon21: 25 residues, 38013280-38013349Exon22: 38 residues, 38017164-38017272Exon23: 68 residues, 38020233-38020433Exon24: 65 residues, 38020974-38021163Exon25: 41 residues, 38021573-38021691Exon26: 32 residues, 38022102-38022193Exon27: 15 residues, 38026534-38026573Exon28: 70 residues, 38031845-38032049Exon29: 23 residues, 38036900-38036964Exon30: 65 residues, 38037316-38037506Exon31: 67 residues, 38038246-38038442Exon32: 40 residues, 38043166-38043282Exon33: 58 residues, 38046418-38046586Exon34: 47 residues, 38047098-38047233Exon35: 52 residues, 38047951-38048101Exon36: 63 residues, 38049797-38049980Exon37: 76 residues, 38050107-38050330Exon38: 22 residues, 38122995-38123055Exon39: 2 residues, -Jump to KI21A_HUMAN  
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