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0KCRU_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCKMT1
DescriptionCreatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0004111 creatine kinase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes .hat reversibly catalyze the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include glycocyamine kinase ().hich catalyzes the transfer of phosphate from ATP to guanidoacetate; arginine kinase ().hich catalyzes the transfer of phosphate from ATP to arginine; taurocyamine kinase ().n annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to taurocyamine; lombricine kinase ().n annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to lombricine; Smc74. cercaria-specific enzyme from Schistosoma mansoni ; and creatine kinase () (CK) which plays an important role in energy metabolism of vertebrates. It catalyzes the reversible transfer of high energy phosphate from ATP to creatine.enerating phosphocreatine and ADP. There are at least four different.ut very closely related.orms of CK. Two isozymes. (muscle) and B (brain).re cytosolic.hile the other two are mitochondrial. In sea urchin there is a flagellar isozyme.hich consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.
  IPR000749:ATP:guanido phosphotransferase
IPR000749:ATP-gua_Ptrans 
Evalue:-194.086181640625 
Location:148-414IPR000749:ATP-gua_PtransN 
Evalue:-54.7212448120117 
Location:52-135
SequencesProtein: KCRU_HUMAN (417 aa)
mRNA: AK223365 NM_001015001 NM_020990
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00933
  Level 3 annotation:
    creatine kinase
  Level 2 annotation:
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 73 residues, 41672543-41672761Exon2: 109 residues, 41673534-41673857Exon3: 68 residues, 41674461-41674660Exon4: 34 residues, 41674863-41674959Exon5: 76 residues, 41675345-41675567Exon6: 30 residues, 41675696-41675782Exon7: 43 residues, 41675897-41676021Exon8: 47 residues, 41677682-41677817Exon9: 44 residues, 41678316-41678442Exon10: 85 residues, 41678646-41678895Exon11: 2 residues, -Jump to KCRU_HUMANExon1: 108 residues, 41673536-41673857Exon2: 68 residues, 41674461-41674660Exon3: 34 residues, 41674863-41674959Exon4: 76 residues, 41675345-41675567Exon5: 30 residues, 41675696-41675782Exon6: 43 residues, 41675897-41676021Exon7: 46 residues, 41677682-41677815Exon8: 44 residues, 41678314-41678442Exon9: 84 residues, 41678646-41678892Exon10: 2 residues, -Jump to KCRU_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 73 residues, 41772375-41772593Exon2: 109 residues, 41773366-41773689Exon3: 68 residues, 41774293-41774492Exon4: 34 residues, 41774695-41774791Exon5: 76 residues, 41775177-41775399Exon6: 30 residues, 41775528-41775614Exon7: 43 residues, 41775729-41775853Exon8: 47 residues, 41777503-41777638Exon9: 44 residues, 41778130-41778256Exon10: 85 residues, 41778462-41778711Exon11: 2 residues, -Jump to KCRU_HUMANExon1: 108 residues, 41773368-41773689Exon2: 68 residues, 41774293-41774492Exon3: 34 residues, 41774695-41774791Exon4: 76 residues, 41775177-41775399Exon5: 30 residues, 41775528-41775614Exon6: 43 residues, 41775729-41775853Exon7: 46 residues, 41777503-41777636Exon8: 44 residues, 41778128-41778256Exon9: 84 residues, 41778462-41778708Exon10: 2 residues, -Jump to KCRU_HUMAN  
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Loci Cluster (Details)Loci: 4166 41276719-41300773 ~-24K 12193(EPB42)(-)Loci: 4167 41312647-41346347 ~-34K 12197(TGM5)(-)Loci: 2884 41450590-41485530 ~-35K 12206(TUBGCP4)(+)Loci: 2885 41672543-41678895 ~-6K 12220(CKMT1)(+)Loci: 2886 41772375-41778711 ~-6K 12228(CKMT1)(+)Loci: 2883 41213013-41264628 ~-52K 12186(+)Link out to UCSC