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0KCNQ2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNQ2
DescriptionPotassium voltage-gated channel subfamily kqt member 2 (voltage-gated potassium channel subunit kv7.2) (neuroblastoma-specific potassium channel alpha subunit kvlqt2) (kqt-like 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008076 voltage-gated potassium channel complex (TAS)
0005249 voltage-gated potassium channel activity (TAS)
0007399 neurogenesis (TAS)
0006813 potassium ion transport (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
KCNQ channels differ from other voltage-gated 6 TM helix channels.hiefly in that they possess no tetramerisation domain. Consequently.hey rely on interaction with accessory subunits.r form heterotetramers with other members of the family . Currently. members of the KCNQ family are known. These have been found to be widely distributed within the body.aving been shown to be expressed in the heart.rain.ancreas.ung.lacenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently.utations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness and benign familial neonatal epilepsy .
  IPR013821:KCNQ voltage-gated potassium channel, C-terminal
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR003091:Voltage-dependent potassium channel
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.KCNQ channels differ from other voltage-gated 6 TM helix channels.hiefly in that they possess no tetramerisation domain. Consequently.hey rely on interaction with accessory subunits.r form heterotetramers with other members of the family . Currently. members of the KCNQ family are known. These have been found to be widely distributed within the body.aving been shown to be expressed in the heart.rain.ancreas.ung.lacenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently.utations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness and benign familial neonatal epilepsy .
  IPR003937:KCNQ voltage-gated potassium channel
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.KCNQ channels differ from other voltage-gated 6 TM helix channels.hiefly in that they possess no tetramerisation domain. Consequently.hey rely on interaction with accessory subunits.r form heterotetramers with other members of the family . Currently. members of the KCNQ family are known. These have been found to be widely distributed within the body.aving been shown to be expressed in the heart.rain.ancreas.ung.lacenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently.utations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness and benign familial neonatal epilepsy .The KCNQ2 channel subunit is thought to form active channels by hetero- tetramerisation with KCNQ3.lthough some K+ channel activity does results from the expression of KCNQ2 alone . Channel function is modulated by phosphorylation.ince experiments have demonstrated that an increase in intracellular cAMP concentration can enhance channel activity. Frameshift mutations in both KCNQ2 and KCNQ3 are associated with benign familial neonatal epilepsy . disorder where an infant begins to suffer convulsions.ithin the first three days of life. These symptoms usually disappear after approximately three months.ut affected individuals have a higher than average chance of subsequently developing epilepsy (10-15%).n later life .
  IPR003947:KCNQ2 voltage-gated potassium channel, N-terminal
IPR005821:Ion_trans 
Evalue:-38.0457572937012 
Location:128-312IPR013821:KCNQ_channel 
Evalue:-6.44369745254517 
Location:445-681IPR003947:KCNQ2CHANNEL 
Evalue:0 
Location:1-20IPR003947:KCNQ2CHANNEL 
Evalue:0 
Location:106-124IPR003947:KCNQ2CHANNEL 
Evalue:0 
Location:21-37
SequencesProtein: KCNQ2_HUMAN (872 aa)
mRNA: NM_172107
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04927
  Level 3 annotation:
    potassium voltage-gated channel, KQT-like subfamily, member 2
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 396 residues, 61507985-61509172Exon2: 43 residues, 61510209-61510333Exon3: 46 residues, 61515246-61515378Exon4: 37 residues, 61515884-61515990Exon5: 76 residues, 61516699-61516923Exon6: 20 residues, 61521415-61521469Exon7: 12 residues, 61525973-61526003Exon8: 25 residues, 61530163-61530232Exon9: 12 residues, 61533136-61533166Exon10: 33 residues, 61535605-61535700Exon11: 34 residues, 61540421-61540517Exon12: 39 residues, 61541394-61541505Exon13: 44 residues, 61544202-61544328Exon14: 60 residues, 61546455-61546631Exon15: 44 residues, 61547034-61547161Exon16: 32 residues, 61548543-61548634Exon17: 159 residues, 61573964-61574437Exon18: 2 residues, -Jump to KCNQ2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC