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0KCNK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNK1
DescriptionPotassium channel subfamily k member 1 (inward rectifying potassium channel protein twik-1) (potassium channel kcno1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0008076 voltage-gated potassium channel complex (TAS)
0005242 inward rectifier potassium channel activity (TAS)
0006813 potassium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry includes the two membrane helix type ion channels found in bacteria .
  IPR013099:Ion transport 2
2P-domain channels influence the resting membrane potential and as a result can control cell excitability. In addition.hey pass K+in response to changes in membrane potential.nd are also tightly regulated by molecular oxygen.ABA (gamma-aminobutyric acid).oradrenaline and serotonin.The first member of this family (TOK1).loned from Saccharomyces cerevisiae .s predicted to have eight potential transmembrane (TM) helices. However.ubsequently-cloned two P-domain family members from Drosophila and mammalian species are predicted to have only four TM segments. They are usually referred to as TWIK-related channels (Tandem of P-domains in a Weakly Inward rectifying K+ channel) . Functional characterisation of these channels has revealed a diversity of properties in that they may show inward or outward rectification.heir activity may be modulated in different directions by protein phosphorylation.nd their sensitivity to changes in intracellular or extracellular pH varies. Despite these disparate properties.hey are all thought to share the same topology of four TM segments.ncluding two P-domains. That TWIK-related K+ channels all produce instantaneous and non-inactivating K+ currents.hich do not display a voltage-dependent activation threshold.uggests that they are background (leak) K+ channels involved in the generation and modulation of the resting membrane potential in various cell types. Further studies have revealed that they may be found in many species.ncluding: plants.nvertebrates and mammals.Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.TWIK-1 was the first two P-domain K+ channel subunit cloned from humantissue . It is widely distributed.eing particularly abundant in thebrain and heart. It forms a weak inward rectifer K+ channel.nd has beenfound to be inhibited by internal acidification; its activity is enhancedby protein kinase C phosphorylation.
  IPR001779:TWIK-1 K+ channel
2P-domain channels influence the resting membrane potential and as a result can control cell excitability. In addition.hey pass K+in response to changes in membrane potential.nd are also tightly regulated by molecular oxygen.ABA (gamma-aminobutyric acid).oradrenaline and serotonin.The first member of this family (TOK1).loned from Saccharomyces cerevisiae .s predicted to have eight potential transmembrane (TM) helices. However.ubsequently-cloned two P-domain family members from Drosophila and mammalian species are predicted to have only four TM segments. They are usually referred to as TWIK-related channels (Tandem of P-domains in a Weakly Inward rectifying K+ channel) . Functional characterisation of these channels has revealed a diversity of properties in that they may show inward or outward rectification.heir activity may be modulated in different directions by protein phosphorylation.nd their sensitivity to changes in intracellular or extracellular pH varies. Despite these disparate properties.hey are all thought to share the same topology of four TM segments.ncluding two P-domains. That TWIK-related K+ channels all produce instantaneous and non-inactivating K+ currents.hich do not display a voltage-dependent activation threshold.uggests that they are background (leak) K+ channels involved in the generation and modulation of the resting membrane potential in various cell types. Further studies have revealed that they may be found in many species.ncluding: plants.nvertebrates and mammals.Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR003280:K+ channel, two pore
2P-domain channels influence the resting membrane potential and as a result can control cell excitability. In addition.hey pass K+in response to changes in membrane potential.nd are also tightly regulated by molecular oxygen.ABA (gamma-aminobutyric acid).oradrenaline and serotonin.The first member of this family (TOK1).loned from Saccharomyces cerevisiae .s predicted to have eight potential transmembrane (TM) helices. However.ubsequently-cloned two P-domain family members from Drosophila and mammalian species are predicted to have only four TM segments. They are usually referred to as TWIK-related channels (Tandem of P-domains in a Weakly Inward rectifying K+ channel) . Functional characterisation of these channels has revealed a diversity of properties in that they may show inward or outward rectification.heir activity may be modulated in different directions by protein phosphorylation.nd their sensitivity to changes in intracellular or extracellular pH varies. Despite these disparate properties.hey are all thought to share the same topology of four TM segments.ncluding two P-domains. That TWIK-related K+ channels all produce instantaneous and non-inactivating K+ currents.hich do not display a voltage-dependent activation threshold.uggests that they are background (leak) K+ channels involved in the generation and modulation of the resting membrane potential in various cell types. Further studies have revealed that they may be found in many species.ncluding: plants.nvertebrates and mammals.Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels. TWIK family members (TWIK-1 and TWIK-2) produce constitutive K+ currents of weak amplitude . They are present in a variety of tissues.ncluding brain and cells of the immune system. Together with their functional properties.heir wide distribution suggests that these channels may be involved in the control of background K+ conductances in many cell types.
  IPR005408:TWIK-1/TWIK-2 K+ channel
IPR013099:Ion_trans_2 
Evalue:-21.8538722991943 
Location:81-158IPR013099:Ion_trans_2 
Evalue:-14.5528421401978 
Location:191-273IPR001779:TWIK1CHANNEL 
Evalue:0 
Location:312-336IPR001779:TWIK1CHANNEL 
Evalue:0 
Location:52-72IPR001779:TWIK1CHANNEL 
Evalue:0 
Location:1-20IPR001779:TWIK1CHANNEL 
Evalue:0 
Location:295-310
SequencesProtein: KCNK1_HUMAN (336 aa)
mRNA: NM_002245
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK04912
  Level 3 annotation:
    potassium channel, subfamily K, member 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 175 residues, 231816372-231816895Exon2: 134 residues, 231868963-231869359Exon3: 324 residues, 231873639-231874607Exon4: 2 residues, -Jump to KCNK1_HUMAN  
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