SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0KCMA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNMA1
DescriptionCalcium-activated potassium channel alpha subunit 1 (calcium-activated potassium channel, subfamily m, alpha subunit 1) (maxi k channel) (maxik) (bk channel) (k(vca)alpha) (bkca alpha) (kca1.1) (slowpoke homolog) (slo homolog) (slo-alpha) (slo1) (hslo).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0016021 integral to membrane (NAS)
0008076 voltage-gated potassium channel complex (TAS)
0015269 calcium-activated potassium channel activity (NAS)
0005515 protein binding (IPI)
0006813 potassium ion transport (NAS)
0007268 synaptic transmission (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1880563308.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.Ca2+-activated K+ channels are a diverse group of channels that are activated by an increase in intracellular Ca2+ concentration. They are found in the majority of nerve cells.here they modulate cell excitability and action potential. Three types of Ca2+-activated K+ channel have been characterised.ermed small-conductance (SK).ntermediate conductance (IK) and large conductance (BK) respectively .BK channels (also referred to as maxi-K channels) are widely expressed in the body.eing found in glandular tissue.mooth and skeletal muscle.s well as in neural tissues. They have been demonstrated to regulate arteriolar and airway diameter.nd also neurotransmitter release. Each channel complex is thought to be composed of 2 types of subunit; the pore-forming (alpha) subunits and smaller accessory (beta) subunits. The alpha subunit of the BK channel was initially thought to share the characteristic 6TM organisation of the voltage-gated K+ channels. However.he molecule is now thought to possess an additional TM domain.ith an extracellular N-terminus and intracellular C-terminus. This C-terminal region contains 4 predominantly hydrophobic domains.hich are also thought to lie intracellularly. The extracellular N-terminus and the first TM region are required for modulation by the beta subunit. The precise location of the Ca2+-binding site that modulates channel activation remains unknown.ut it is thought to lie within the C-terminal hydrophobic domains.
  IPR003929:Calcium-activated BK potassium channel, alpha subunit
InterPro domains unassigned to SynO:
This group of proteins is found in sodium.otassium.nd calcium ion channels proteins. The proteins have 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some Na channels proteins the domain is repeated four times.hereas in others (e.g. K channels) the protein forms a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not included in the Pfam family due to it lacking the first four helices.
  IPR005821:Ion transport
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR003091:Voltage-dependent potassium channel
IPR003929:BK_channel_a 
Evalue:-62.4948501586914 
Location:536-674IPR005821:Ion_trans 
Evalue:-26.3665313720703 
Location:216-387IPR003929:BKCHANNELA 
Evalue:0 
Location:482-502IPR003929:BKCHANNELA 
Evalue:0 
Location:439-459IPR003929:BKCHANNELA 
Evalue:0 
Location:1190-1205IPR003929:BKCHANNELA 
Evalue:0 
Location:1013-1028IPR003929:BKCHANNELA 
Evalue:0 
Location:765-779IPR003929:BKCHANNELA 
Evalue:0 
Location:515-528IPR002052:N6_MTASE 
Evalue:0 
Location:1156-1162IPR003006:IG_MHC 
Evalue:0 
Location:0-0
SequencesProtein: KCMA1_HUMAN (1236 aa)
mRNA: AB113382 NM_001014797 NM_002247
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords,domains)
?
sdb:0223 transmitter release  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04936
  Level 3 annotation:
    potassium large conductance calcium-activated channel, subfamily M, alpha member 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 2763 residues, 78299369-78307657Exon2: 77 residues, 78317054-78317279Exon3: 41 residues, 78319214-78319333Exon4: 67 residues, 78321288-78321483Exon5: 45 residues, 78339729-78339860Exon6: 40 residues, 78344699-78344813Exon7: 66 residues, 78374536-78374729Exon8: 77 residues, 78378905-78379130Exon9: 43 residues, 78383564-78383688Exon10: 33 residues, 78399737-78399831Exon11: 27 residues, 78441730-78441807Exon12: 31 residues, 78448776-78448863Exon13: 6 residues, 78455209-78455221Exon14: 25 residues, 78457586-78457655Exon15: 38 residues, 78469291-78469401Exon16: 54 residues, 78502860-78503016Exon17: 25 residues, 78509244-78509314Exon18: 29 residues, 78514400-78514483Exon19: 37 residues, 78516251-78516357Exon20: 39 residues, 78520163-78520274Exon21: 32 residues, 78538244-78538336Exon22: 59 residues, 78539936-78540107Exon23: 27 residues, 78542130-78542206Exon24: 27 residues, 78550736-78550812Exon25: 39 residues, 78613184-78613296Exon26: 33 residues, 78614586-78614680Exon27: 22 residues, 78680958-78681020Exon28: 56 residues, 78833625-78833787Exon29: 187 residues, 79067028-79067583Exon30: 2 residues, -Jump to KCMA1_HUMANExon1: 880 residues, 78314641-78317279Exon2: 41 residues, 78319214-78319333Exon3: 67 residues, 78321288-78321483Exon4: 45 residues, 78339729-78339860Exon5: 40 residues, 78344699-78344813Exon6: 66 residues, 78374536-78374729Exon7: 77 residues, 78378905-78379130Exon8: 43 residues, 78383564-78383688Exon9: 33 residues, 78399737-78399831Exon10: 27 residues, 78441730-78441807Exon11: 31 residues, 78448776-78448863Exon12: 25 residues, 78457586-78457655Exon13: 38 residues, 78469291-78469401Exon14: 54 residues, 78502860-78503016Exon15: 25 residues, 78509244-78509314Exon16: 29 residues, 78514400-78514483Exon17: 37 residues, 78516251-78516357Exon18: 39 residues, 78520163-78520274Exon19: 32 residues, 78538244-78538336Exon20: 59 residues, 78539936-78540107Exon21: 27 residues, 78542130-78542206Exon22: 27 residues, 78550736-78550812Exon23: 39 residues, 78613184-78613296Exon24: 33 residues, 78614586-78614680Exon25: 22 residues, 78680958-78681020Exon26: 56 residues, 78833625-78833787Exon27: 187 residues, 79067028-79067583Exon28: 2 residues, -Jump to KCMA1_HUMANExon1: 117 residues, 78316931-78317279Exon2: 41 residues, 78319214-78319333Exon3: 67 residues, 78321288-78321483Exon4: 45 residues, 78339729-78339860Exon5: 40 residues, 78344699-78344813Exon6: 66 residues, 78374536-78374729Exon7: 77 residues, 78378905-78379130Exon8: 43 residues, 78383564-78383688Exon9: 33 residues, 78399737-78399831Exon10: 60 residues, 78431170-78431344Exon11: 27 residues, 78441730-78441807Exon12: 31 residues, 78448776-78448863Exon13: 25 residues, 78457586-78457655Exon14: 38 residues, 78469291-78469401Exon15: 54 residues, 78502860-78503016Exon16: 25 residues, 78509244-78509314Exon17: 29 residues, 78514400-78514483Exon18: 37 residues, 78516251-78516357Exon19: 39 residues, 78520163-78520274Exon20: 32 residues, 78538244-78538336Exon21: 59 residues, 78539936-78540107Exon22: 27 residues, 78542130-78542206Exon23: 27 residues, 78550736-78550812Exon24: 39 residues, 78613184-78613296Exon25: 33 residues, 78614586-78614680Exon26: 22 residues, 78680958-78681020Exon27: 56 residues, 78833625-78833787Exon28: 108 residues, 79067028-79067348Exon29: 2 residues, -Jump to KCMA1_HUMAN