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0KCIP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNIP1
DescriptionKv channel-interacting protein 1 (kchip1) (a-type potassium channel modulatory protein 1) (potassium channel-interacting protein 1) (vesicle apc-binding protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005513 calcium ion sensing (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
Recoverin. retinal calcium-binding protein.elongs to the larger family ofproteins which have an EF-hand calcium-binding domain. Recoverinparticipates in the recovery phase of visual excitation and in adaption to light.The Ca2+-bound form of recoverin prolongs the photoresponse.resumably by blockingphosphorylation of photoexcited rhodopsin. Recoverin contains a covalently-attachedmyristoyl group.r acyl group.t its N-terminus.nd two Ca2+-binding sites .A number of other proteins including visinin.ippocalcin.eurocalcin.-modulin.isinin-like protein.nd frequenin belong to this family. All of thefamily memebers have the aromatic residues that contribute to the myristoyl-bindingpocket.
  IPR001125:Recoverin
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR002048:efhand 
Evalue:-6.24412536621094 
Location:137-165IPR002048:efhand 
Evalue:-4.11350917816162 
Location:185-213IPR002048:efhand 
Evalue:-1.25963735580444 
Location:101-129IPR001125:RECOVERIN 
Evalue:0 
Location:59-78
SequencesProtein: KCIP1_HUMAN (227 aa)
mRNA: NM_001034837
Local Annotation
Synapse Ontology
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 197 residues, 169863625-169864215Exon2: 13 residues, 170072435-170072468Exon3: 43 residues, 170078339-170078464Exon4: 25 residues, 170079902-170079972Exon5: 25 residues, 170081414-170081485Exon6: 38 residues, 170082294-170082402Exon7: 37 residues, 170092381-170092486Exon8: 23 residues, 170093417-170093480Exon9: 292 residues, 170095340-170096212Exon10: 2 residues, -Jump to KCIP1_HUMAN  
Loci Cluster (Details)Loci: 3508 169863625-170096212 ~-233K 29918(KCNIP1)(+)Loci: 3509 170143342-170173626 ~-30K 29921(GABRP)(+)Loci: 4753 169737744-169749216 ~-11K 29917(KCNMB1)(-)Link out to UCSC