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0KCC2G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCAMK2G
DescriptionCalcium/calmodulin-dependent protein kinase type ii gamma chain (ec 2.7.1.123) (cam-kinase ii gamma chain) (cam kinase ii gamma subunit) (camk-ii gamma subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005524 ATP binding (NAS)
0004685 calcium- and calmodulin-dependent protein k... (NAS)
0004723 calcium-dependent protein serine/threonine ... (NAS)
0005516 calmodulin binding (NAS)
0030073 insulin secretion (NAS)
0006468 protein amino acid phosphorylation (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
This domain is found at the C terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain () at their N terminus . The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers .
  IPR013543:Calcium/calmodulin dependent protein kinase II, association-domain
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-105.214670164989 
Location:14-272IPR013543:CaMKII_AD 
Evalue:-86.6197891235352 
Location:426-553
SequencesProtein: KCC2G_HUMAN (558 aa)
mRNA: NM_172171
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
?
sdb:0223 transmitter release  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK04515
  Level 3 annotation:
    calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Level 2 annotation:
    Wnt signaling pathway
    Calcium signaling pathway
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 669 residues, 75242264-75244269Exon2: 83 residues, 75244766-75245011Exon3: 33 residues, 75246786-75246881Exon4: 27 residues, 75247242-75247318Exon5: 40 residues, 75249295-75249409Exon6: 18 residues, 75251445-75251494Exon7: 17 residues, 75253803-75253848Exon8: 25 residues, 75255042-75255111Exon9: 16 residues, 75267231-75267275Exon10: 16 residues, 75271932-75271975Exon11: 30 residues, 75272221-75272305Exon12: 43 residues, 75276988-75277111Exon13: 33 residues, 75277751-75277846Exon14: 30 residues, 75278289-75278373Exon15: 36 residues, 75278776-75278879Exon16: 26 residues, 75279024-75279097Exon17: 24 residues, 75282017-75282083Exon18: 20 residues, 75282955-75283010Exon19: 22 residues, 75290593-75290653Exon20: 33 residues, 75302752-75302847Exon21: 63 residues, 75304160-75304344Exon22: 2 residues, -Jump to KCC2G_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3900 75242264-75304344 ~-62K 5158(CAMK2G)(-)Loci: 3901 75551522-75580793 ~-29K 5169(AP3M1)(-)Loci: 3899 75074650-75085838 ~-11K 5150(SYNPO2L)(-)Link out to UCSC