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0KCC2A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCAMK2A
DescriptionCalcium/calmodulin-dependent protein kinase type ii alpha chain (ec 2.7.1.123) (cam-kinase ii alpha chain) (cam kinase ii alpha subunit) (camk-ii alpha subunit).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
This domain is found at the C terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain () at their N terminus . The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers .
  IPR013543:Calcium/calmodulin dependent protein kinase II, association-domain
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-106.45593195565 
Location:13-271IPR013543:CaMKII_AD 
Evalue:-90.5686340332031 
Location:346-473
SequencesProtein: KCC2A_HUMAN (478 aa)
mRNA: AF145710 AF145711 NM_015981 NM_171825
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
?
sdb:0223 transmitter release  (Evidence:keywords)
?
sdb:0297 NMDA receptor  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK04515
  Level 3 annotation:
    calcium/calmodulin-dependent protein kinase (CaM kinase) II
  Level 2 annotation:
    Wnt signaling pathway
    Calcium signaling pathway
    Long-term potentiation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 5 residues, 149563423-149563437Exon2: 79 residues, 149582740-149582973Exon3: 33 residues, 149587947-149588042Exon4: 27 residues, 149591060-149591136Exon5: 18 residues, 149598455-149598504Exon6: 13 residues, 149599459-149599492Exon7: 15 residues, 149604916-149604957Exon8: 16 residues, 149607527-149607570Exon9: 30 residues, 149609981-149610065Exon10: 43 residues, 149610443-149610566Exon11: 33 residues, 149611505-149611600Exon12: 30 residues, 149611737-149611821Exon13: 36 residues, 149613199-149613302Exon14: 26 residues, 149616328-149616401Exon15: 24 residues, 149616521-149616587Exon16: 20 residues, 149617318-149617373Exon17: 22 residues, 149624711-149624771Exon18: 33 residues, 149632820-149632915Exon19: 24 residues, 149649319-149649385Exon20: 2 residues, -Jump to KCC2A_HUMANExon1: 5 residues, 149563423-149563437Exon2: 79 residues, 149582740-149582973Exon3: 33 residues, 149587947-149588042Exon4: 27 residues, 149591060-149591136Exon5: 18 residues, 149598455-149598504Exon6: 15 residues, 149604916-149604957Exon7: 16 residues, 149607527-149607570Exon8: 30 residues, 149609981-149610065Exon9: 43 residues, 149610443-149610566Exon10: 33 residues, 149611505-149611600Exon11: 30 residues, 149611737-149611821Exon12: 36 residues, 149613199-149613302Exon13: 26 residues, 149616328-149616401Exon14: 24 residues, 149616521-149616587Exon15: 20 residues, 149617318-149617373Exon16: 22 residues, 149624711-149624771Exon17: 33 residues, 149632820-149632915Exon18: 24 residues, 149649319-149649385Exon19: 2 residues, -Jump to KCC2A_HUMANExon1: 1075 residues, 149579247-149582469Exon2: 78 residues, 149582744-149582973Exon3: 33 residues, 149587947-149588042Exon4: 27 residues, 149591060-149591136Exon5: 18 residues, 149598455-149598504Exon6: 13 residues, 149599459-149599492Exon7: 15 residues, 149604916-149604957Exon8: 16 residues, 149607527-149607570Exon9: 30 residues, 149609981-149610065Exon10: 43 residues, 149610443-149610566Exon11: 33 residues, 149611505-149611600Exon12: 30 residues, 149611737-149611821Exon13: 36 residues, 149613199-149613302Exon14: 26 residues, 149616328-149616401Exon15: 24 residues, 149616521-149616587Exon16: 20 residues, 149617318-149617373Exon17: 22 residues, 149624711-149624771Exon18: 33 residues, 149632820-149632915Exon19: 72 residues, 149649319-149649529Exon20: 2 residues, -Jump to KCC2A_HUMANExon1: 1075 residues, 149579247-149582469Exon2: 78 residues, 149582744-149582973Exon3: 33 residues, 149587947-149588042Exon4: 27 residues, 149591060-149591136Exon5: 18 residues, 149598455-149598504Exon6: 15 residues, 149604916-149604957Exon7: 16 residues, 149607527-149607570Exon8: 30 residues, 149609981-149610065Exon9: 43 residues, 149610443-149610566Exon10: 33 residues, 149611505-149611600Exon11: 30 residues, 149611737-149611821Exon12: 36 residues, 149613199-149613302Exon13: 26 residues, 149616328-149616401Exon14: 24 residues, 149616521-149616587Exon15: 20 residues, 149617318-149617373Exon16: 22 residues, 149624711-149624771Exon17: 33 residues, 149632820-149632915Exon18: 72 residues, 149649319-149649529Exon19: 2 residues, -Jump to KCC2A_HUMAN  
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Loci Cluster (Details)Loci: 4743 149563423-149649529 ~-86K 29756(CAMK2A)(-)Loci: 4744 149656101-149662641 ~-7K 29760(ARSI)(-)Loci: 3502 149960834-150012089 ~-51K 29771(SYNPO)(+)Loci: 4745 150068502-150118769 ~-50K 29777(DCTN4)(-)Loci: 3501 149549712-149570827 ~-21K 29755(SLC6A7)(+)Link out to UCSC