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0KCC1G_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCAMK1G
DescriptionCalcium/calmodulin-dependent protein kinase type 1g (ec 2.7.1.123) (cam kinase ig) (cam kinase i gamma) (camki gamma) (camki-gamma) (cam- ki gamma) (camkig) (camk-like creb kinase iii) (click iii).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . CAUTION: Despite SMART having created two different HMMs for Serine/Threonine protein kinase and for Tyrosine protein kinase.arge number of proteins match both signatures.s SMART considers it to be natural for these two closely related families.
  IPR002290:Serine/threonine protein kinase
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR002290:S_TKc 
Evalue:-110.698970004336 
Location:23-277
SequencesProtein: KCC1G_HUMAN (476 aa)
mRNA: NM_020439
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
calcium-regulated transcription factor
sdb:0215 calcium-regulated transcription factor  (Evidence:keywords)
KO assignmentK00908
  Level 3 annotation:
    Ca2+/calmodulin-dependent protein kinase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 25 residues, 207823667-207823740Exon2: 42 residues, 207834922-207835043Exon3: 45 residues, 207839950-207840079Exon4: 27 residues, 207843181-207843256Exon5: 48 residues, 207845503-207845642Exon6: 43 residues, 207846287-207846411Exon7: 27 residues, 207847825-207847901Exon8: 39 residues, 207848947-207849060Exon9: 28 residues, 207849818-207849897Exon10: 31 residues, 207851432-207851520Exon11: 143 residues, 207851759-207852184Exon12: 44 residues, 207852752-207852880Exon13: 301 residues, 207853007-207853906Exon14: 2 residues, -Jump to KCC1G_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2587 207926172-207974917 ~-49K 3858(HSD11B1)(+)Loci: 2588 208178218-208402294 ~-224K 3867(SYT14)(+)Loci: 2586 207823667-207853906 ~-30K 3854(CAMK1G)(+)Link out to UCSC