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0KCAB1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNAB1
DescriptionVoltage-gated potassium channel beta-1 subunit (k(+) channel beta-1 subunit) (kv-beta-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0015459 potassium channel regulator activity (TAS)
0006813 potassium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The aldo-keto reductase family includes a number of related monomeric NADPH-dependent oxidoreductases.uch as aldehyde reductase.ldose reductase.rostaglandin F synthase.ylose reductase.ho crystallin.nd many others . All possess a similar structure.ith a beta-alpha-beta fold characteristic of nucleotide binding proteins . The fold comprises a parallel beta-8/alpha-8-barrel.hich contains a novel NADP-binding motif. The binding site is located in a large.eep.lliptical pocket in the C-terminal end of the beta sheet.he substrate being bound in an extended conformation. The hydrophobic nature of the pocket favours aromatic and apolar substrates over highly polar ones . Binding of the NADPH coenzyme causes a massive conformational change.eorienting a loop.ffectively locking the coenzyme in place. This binding is more similar to FAD- than to NAD(P)-binding oxidoreductases . Some proteins of this entry contain a K+ ion channel beta chain regulatory domain; these are reported to have oxidoreductase activity .
  IPR001395:Aldo/keto reductase
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels. Some types of K+ channel are closed at the resting potential of the cell.ut open on membrane depolarisation.nd are thus known as voltage-gated channels. Each of these types of channel typically comprises 4 pore-forming alpha subunits that may associate with one of a number of different types of beta subunit. Two types of beta subunit (KCNE and KCNAB) are presently known to associate with voltage-gated alpha subunits (Kv.CNQ and eag-like). However.ot all combinations of alpha and beta subunits are possible.
  IPR005399:KCNAB voltage-gated K+ channel, beta subunit
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels. Some types of K+ channel are closed at the resting potential of the cell.ut open on membrane depolarisation.nd are thus known as voltage-gated channels. Each of these types of channel typically comprises 4 pore-forming alpha subunits that may associate with one of a number of different types of beta subunit. Two types of beta subunit (KCNE and KCNAB) are presently known to associate with voltage-gated alpha subunits (Kv.CNQ and eag-like). However.ot all combinations of alpha and beta subunits are possible. KCNAB1 associates with Kv1.4 and Kv1.5 alpha subunits and appears to have an N-terminal sequence that is similar to the Kv1 channel inactivation gate. Thus.hen KCNAB1 subunits associate.heir N-termini appear to be able to substitute for alpha subunit inactivation gates . Three isoforms of KCNAB1 exist.hich are produced by alternative splicing of the N-terminal 90 amino acids. KCNAB1 channels are expressed in brain (caudate nucleus.ippocampus.mygdala.ubthalamic nucleus and thalamus) and heart.
  IPR005400:KCNAB voltage-gated K+ channel, beta-1 subunit
Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.This entry represents the conserved core region of the beta subunit of voltage-gated potassium (Kv) channels in animals. Amino-terminal regions differ substantially.n part by alternative splicing.nd are not included in the model. Four beta subunits form a complex with four alpha subunit cytoplasmic (T1) regions.nd the structure of the complex is solved. The beta subunit belongs to a family of NAD(P)H-dependent aldo-keto reductases.inds NADPH.nd couples voltage-gated channel activity to the redox potential of the cell. Plant beta subunits and their closely related bacterial homologs (in Deinococcus radiodurans.ylella fastidiosa.tc.) appear more closely related to each other than to animal forms. However.he bacterial species lack convincing counterparts the Kv alpha subunit and the Kv beta homolog may serve as an enzyme.
  IPR005983:KCNAB voltage-gated K+ channel, beta subunit, eukaryotic type
IPR001395:Aldo_ket_red 
Evalue:-99.3665313720703 
Location:95-408
SequencesProtein: KCAB1_HUMAN (419 aa)
mRNA: NM_172160
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentK04882
  Level 3 annotation:
    potassium voltage-gated channel, Shaker-related subfamily A, beta member 1
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 110 residues, 157321041-157321369Exon2: 16 residues, 157622098-157622142Exon3: 14 residues, 157653381-157653419Exon4: 28 residues, 157657935-157658015Exon5: 17 residues, 157660309-157660354Exon6: 17 residues, 157664184-157664229Exon7: 16 residues, 157666125-157666169Exon8: 31 residues, 157675216-157675303Exon9: 30 residues, 157714846-157714932Exon10: 42 residues, 157715582-157715703Exon11: 33 residues, 157716752-157716847Exon12: 42 residues, 157724309-157724430Exon13: 31 residues, 157731891-157731980Exon14: 651 residues, 157737140-157739087Exon15: 2 residues, -Jump to KCAB1_HUMAN