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0KC1D_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionCasein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004681 casein kinase I activity (TAS)
0006281 DNA repair (TAS)
0006468 protein amino acid phosphorylation (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
SequencesProtein: KC1D_HUMAN (415 aa)
mRNA: NM_001893 NM_139062
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK02218
  Level 3 annotation:
    casein kinase 1
  Level 2 annotation:
    Hedgehog signaling pathway
    Gap junction
    Circadian rhythm
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 156 residues, 77795530-77795996Exon2: 48 residues, 77800039-77800179Exon3: 59 residues, 77800595-77800767Exon4: 51 residues, 77802543-77802692Exon5: 59 residues, 77803598-77803769Exon6: 78 residues, 77804180-77804409Exon7: 51 residues, 77806593-77806742Exon8: 39 residues, 77816850-77816961Exon9: 132 residues, 77824470-77824862Exon10: 2 residues, -Jump to KC1D_HUMANExon1: 156 residues, 77795530-77795996Exon2: 23 residues, 77797140-77797204Exon3: 48 residues, 77800039-77800179Exon4: 59 residues, 77800595-77800767Exon5: 51 residues, 77802543-77802692Exon6: 59 residues, 77803598-77803769Exon7: 78 residues, 77804180-77804409Exon8: 51 residues, 77806593-77806742Exon9: 39 residues, 77816850-77816961Exon10: 132 residues, 77824470-77824862Exon11: 2 residues, -Jump to KC1D_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4323 76816673-76827450 ~-11K 16811(-)Loci: 4324 77091593-77094422 ~-3K 16823(ACTG1)(-)Loci: 3047 77261424-77279550 ~-18K 16838(HGS)(+)Loci: 3048 77451912-77454066 ~-2K 16852(NPB)(+)Loci: 3049 77603051-77608635 ~-6K 16881(GPS1)(+)Loci: 4325 77629503-77649395 ~-20K 16888(FASN)(-)Loci: 4326 77795530-77824862 ~-29K 16893(CSNK1D)(-)Loci: 4327 78208237-78249802 ~-42K 16919(RAB40B)(-)Loci: 3046 76623556-76705827 ~-82K 16801(BAIAP2)(+)Link out to UCSC