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0KC1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCSNK1A1
DescriptionCasein kinase i, alpha isoform (ec 2.7.1.-) (cki-alpha) (ck1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004681 casein kinase I activity (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0006468 protein amino acid phosphorylation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
IPR000719:Pkinase 
Evalue:-37.6020584106445 
Location:17-240
SequencesProtein: KC1A_HUMAN (337 aa)
mRNA: NM_001025105 NM_001892
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentK02218
  Level 3 annotation:
    casein kinase 1
  Level 2 annotation:
    Hedgehog signaling pathway
    Gap junction
    Circadian rhythm
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 527 residues, 148855037-148856616Exon2: 51 residues, 148865202-148865351Exon3: 37 residues, 148866782-148866889Exon4: 27 residues, 148869634-148869709Exon5: 28 residues, 148871549-148871628Exon6: 48 residues, 148872825-148872965Exon7: 30 residues, 148877549-148877633Exon8: 35 residues, 148880045-148880144Exon9: 44 residues, 148884800-148884927Exon10: 37 residues, 148909830-148909937Exon11: 203 residues, 148910597-148911200Exon12: 2 residues, -Jump to KC1A_HUMANExon1: 527 residues, 148855037-148856616Exon2: 51 residues, 148865202-148865351Exon3: 37 residues, 148866782-148866889Exon4: 27 residues, 148869634-148869709Exon5: 28 residues, 148871549-148871628Exon6: 48 residues, 148872825-148872965Exon7: 35 residues, 148880045-148880144Exon8: 44 residues, 148884800-148884927Exon9: 37 residues, 148909830-148909937Exon10: 203 residues, 148910597-148911200Exon11: 2 residues, -Jump to KC1A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3499 148185000-148188447 ~-3K 29722(ADRB2)(+)Loci: 4741 148364376-148422880 ~-59K 29724(SH3TC2)(-)Loci: 3500 148705284-148714338 ~-9K 29730(GRPEL2)(+)Loci: 4742 148855037-148911200 ~-56K 29736(CSNK1A1)(-)Loci: 4740 147841291-148013909 ~-173K 29718(HTR4)(-)Link out to UCSC