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0KBL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGCAT
Description2-amino-3-ketobutyrate coenzyme a ligase, mitochondrial precursor (ec 2.3.1.29) (akb ligase) (glycine acetyltransferase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (NAS)
0008890 glycine C-acetyltransferase activity (NAS)
0006520 amino acid metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes.uch as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity.hese various enzymes can be grouped into class I and class II. This entry includes proteins from both subfamilies.
  IPR004839:Aminotransferase, class I and II
This entry represents a narrowly defined clade of animal and bacterial (almost exclusively proteobacterial) 2-amino-3-ketobutyrate--CoA ligase. This enzyme can act in threonine catabolism. The closest homologue from Bacillus subtilis.nd sequences like it.ay be functionally equivalent but were not included in the model because of difficulty in finding reports of function.
  IPR011282:2-amino-3-ketobutyrate coenzyme A ligase
IPR004839:Aminotran_1_2 
Evalue:-80.9208221435547 
Location:65-408
SequencesProtein: KBL_HUMAN (419 aa)
mRNA: AK123190 NM_014291
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00639
  Level 3 annotation:
    glycine C-acetyltransferase
  Level 2 annotation:
    Glycine
     serine and threonine metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 76 residues, 36533890-36534116Exon2: 71 residues, 36535901-36536110Exon3: 36 residues, 36538839-36538941Exon4: 51 residues, 36539415-36539562Exon5: 53 residues, 36541078-36541233Exon6: 29 residues, 36541370-36541453Exon7: 59 residues, 36541615-36541787Exon8: 42 residues, 36542152-36542274Exon9: 55 residues, 36542519-36542678Exon10: 84 residues, 36542881-36543129Exon11: 2 residues, -Jump to KBL_HUMANExon1: 73 residues, 36533900-36534116Exon2: 45 residues, 36535979-36536110Exon3: 36 residues, 36538839-36538941Exon4: 51 residues, 36539415-36539562Exon5: 53 residues, 36541078-36541233Exon6: 29 residues, 36541370-36541453Exon7: 59 residues, 36541615-36541787Exon8: 42 residues, 36542152-36542274Exon9: 112 residues, 36542519-36542849Exon10: 2 residues, -Jump to KBL_HUMAN  
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Loci Cluster (Details)Loci: 3313 36334448-36359516 ~-25K 24689(GGA1)(+)Loci: 3314 36365427-36392885 ~-27K 24693(+)Loci: 3315 36533890-36543129 ~-9K 24705(GCAT)(+)Loci: 3316 36549334-36551448 ~-2K 24707(GALR3)(+)Loci: 3317 36783348-36801653 ~-18K 24722(PRKCABP)(+)Loci: 4568 36810855-36836622 ~-26K 24725(-)Loci: 4569 37152280-37181149 ~-29K 24733(KCNJ4)(-)Loci: 4570 37209390-37232262 ~-23K 24737(DDX17)(-)Loci: 4571 37460680-37481928 ~-21K 24750(UNC84B)(-)Loci: 4567 35932191-35938299 ~-6K 24676(SSTR3)(-)Link out to UCSC