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0K1C17_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKRT17
DescriptionKeratin, type i cytoskeletal 17 (cytokeratin 17) (k17) (ck 17) (39.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005882 intermediate filament (TAS)
0005200 structural constituent of cytoskeleton (TAS)
0008544 epidermis development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin.esmin.lial fibrillary acidic protein (GFAP).eripherin.nd plasticin.Type IV: Neurofilaments L. and M.lpha-internexin and nestin.Type V: Nuclear lamins A.1.2 and C.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices.ith at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical.nd which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related.hey have limited sequence homologies except in several regions of the rod domain.
  IPR001664:Intermediate filament protein
Keratins are a well known group of intermediate filament proteins. Like actin filaments.eratins are flexible but provide a firm cell skeleton.Unlike actin.owever.o known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw.ith a further 20 found in internal body cavity epithelia. They are alsofound at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively) .Type I keratins are a group of acidic intermediate filament proteins thatexist as chains of hetero-dimers with basic type II keratins. Each typeI keratin consists of head-.od- and tail-like structures.he rod beingconstructed from three linked coils: 1A.B and 2. Type I proteins are associated with a number of inherited developmental disorders.uch as baldness.eading of hair.nd skin blistering.
  IPR002957:Keratin, type I
This domain consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011000:Apolipophorin III-like
IPR001664:Filament 
Evalue:-183.920822143555 
Location:82-393
SequencesProtein: K1C17_HUMAN (431 aa)
mRNA: NM_000422
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK07604
  Level 3 annotation:
    type I keratin, acidic
  Level 2 annotation:
    Membrane and intracellular structural molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 83 residues, 37029220-37029466Exon2: 9 residues, 37030313-37030336Exon3: 75 residues, 37030436-37030657Exon4: 44 residues, 37030743-37030869Exon5: 56 residues, 37031370-37031532Exon6: 54 residues, 37032132-37032289Exon7: 29 residues, 37032727-37032810Exon8: 162 residues, 37033855-37034335Exon9: 2 residues, -Jump to K1C17_HUMAN  
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Loci Cluster (Details)Loci: 4286 37029220-37034335 ~-5K 15835(KRT17)(-)Loci: 4285 36992058-36996673 ~-5K 15831(KRT14)(-)Link out to UCSC