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0K1C14_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKRT14
DescriptionKeratin, type i cytoskeletal 14 (cytokeratin 14) (k14) (ck 14).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005200 structural constituent of cytoskeleton (TAS)
0008544 epidermis development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Intermediate filaments (IF) are proteins which are primordial components of the cytoskeleton and the nuclear envelope. They generally form filamentous structures 8 to 14 nm wide.IF proteins are members of a very large multigene family of proteins which has been subdivided in five major subgroups:Type I: Acidic cytokeratins.Type II: Basic cytokeratins.Type III: Vimentin.esmin.lial fibrillary acidic protein (GFAP).eripherin.nd plasticin.Type IV: Neurofilaments L. and M.lpha-internexin and nestin.Type V: Nuclear lamins A.1.2 and C.All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled alpha-helices.ith at least two short characteristic interruptions; a N-terminal non-helical domain (head) of variable length; and a C-terminal domain (tail) which is also non-helical.nd which shows extreme length variation between different IF proteins.While IF proteins are evolutionary and structurally related.hey have limited sequence homologies except in several regions of the rod domain.
  IPR001664:Intermediate filament protein
Keratins are a well known group of intermediate filament proteins. Like actin filaments.eratins are flexible but provide a firm cell skeleton.Unlike actin.owever.o known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw.ith a further 20 found in internal body cavity epithelia. They are alsofound at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively) .Type I keratins are a group of acidic intermediate filament proteins thatexist as chains of hetero-dimers with basic type II keratins. Each typeI keratin consists of head-.od- and tail-like structures.he rod beingconstructed from three linked coils: 1A.B and 2. Type I proteins are associated with a number of inherited developmental disorders.uch as baldness.eading of hair.nd skin blistering.
  IPR002957:Keratin, type I
IPR001664:Filament 
Evalue:-193.091522216797 
Location:113-424
SequencesProtein: K1C14_HUMAN (471 aa)
mRNA: NM_000526
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
KO assignmentK07604
  Level 3 annotation:
    type I keratin, acidic
  Level 2 annotation:
    Membrane and intracellular structural molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 85 residues, 36992058-36992310Exon2: 17 residues, 36992871-36992918Exon3: 75 residues, 36993012-36993233Exon4: 44 residues, 36993328-36993454Exon5: 56 residues, 36993537-36993699Exon6: 54 residues, 36994034-36994191Exon7: 29 residues, 36994752-36994835Exon8: 197 residues, 36996087-36996673Exon9: 2 residues, -Jump to K1C14_HUMAN  
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Loci Cluster (Details)Loci: 4286 37029220-37034335 ~-5K 15835(KRT17)(-)Loci: 4285 36992058-36996673 ~-5K 15831(KRT14)(-)Link out to UCSC