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0JIP3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPK8IP3
DescriptionC-jun-amino-terminal kinase interacting protein 3 (jnk-interacting protein 3) (jip-3) (jnk map kinase scaffold protein 3) (mitogen- activated protein kinase 8-interacting protein 3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (ISS)
0019894 kinesin binding (ISS)
0005078 MAP-kinase scaffold activity (ISS)
0019901 protein kinase binding (ISS)
0046328 regulation of JNK cascade (ISS)
0016192 vesicle-mediated transport (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
IPR011046:WD40_like 
Evalue:0 
Location:954-1175IPR011046:WD40_like 
Evalue:0 
Location:1315-1333
SequencesProtein: JIP3_HUMAN (1334 aa)
mRNA: NM_015133 NM_033392
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK04436
  Level 3 annotation:
    mitogen-activated protein kinase 8 interacting protein 3
  Level 2 annotation:
    MAPK signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 147 residues, 1696221-1696659Exon2: 42 residues, 1714558-1714679Exon3: 25 residues, 1719139-1719210Exon4: 32 residues, 1719488-1719580Exon5: 50 residues, 1733333-1733478Exon6: 84 residues, 1737030-1737277Exon7: 36 residues, 1738245-1738348Exon8: 41 residues, 1738603-1738722Exon9: 30 residues, 1749932-1750017Exon10: 53 residues, 1750381-1750534Exon11: 29 residues, 1751225-1751307Exon12: 45 residues, 1752352-1752483Exon13: 21 residues, 1752676-1752733Exon14: 59 residues, 1752837-1753008Exon15: 44 residues, 1753658-1753785Exon16: 34 residues, 1754116-1754212Exon17: 55 residues, 1754302-1754461Exon18: 57 residues, 1755014-1755180Exon19: 63 residues, 1755961-1756144Exon20: 65 residues, 1756221-1756411Exon21: 42 residues, 1756530-1756650Exon22: 29 residues, 1756724-1756805Exon23: 24 residues, 1756905-1756973Exon24: 53 residues, 1757150-1757303Exon25: 64 residues, 1757551-1757737Exon26: 40 residues, 1757806-1757920Exon27: 15 residues, 1758070-1758109Exon28: 62 residues, 1758200-1758380Exon29: 52 residues, 1758478-1758628Exon30: 540 residues, 1758704-1760318Exon31: 2 residues, -Jump to JIP3_HUMANExon1: 147 residues, 1696221-1696659Exon2: 42 residues, 1714558-1714679Exon3: 25 residues, 1719139-1719210Exon4: 32 residues, 1719488-1719580Exon5: 49 residues, 1733336-1733478Exon6: 84 residues, 1737030-1737277Exon7: 36 residues, 1738245-1738348Exon8: 41 residues, 1738603-1738722Exon9: 6 residues, 1748149-1748161Exon10: 8 residues, 1748979-1748997Exon11: 21 residues, 1749959-1750017Exon12: 53 residues, 1750381-1750534Exon13: 29 residues, 1751225-1751307Exon14: 45 residues, 1752352-1752483Exon15: 21 residues, 1752676-1752733Exon16: 59 residues, 1752837-1753008Exon17: 44 residues, 1753658-1753785Exon18: 34 residues, 1754116-1754212Exon19: 55 residues, 1754302-1754461Exon20: 57 residues, 1755014-1755180Exon21: 63 residues, 1755961-1756144Exon22: 65 residues, 1756221-1756411Exon23: 42 residues, 1756530-1756650Exon24: 29 residues, 1756724-1756805Exon25: 24 residues, 1756905-1756973Exon26: 51 residues, 1757150-1757299Exon27: 59 residues, 1757565-1757737Exon28: 40 residues, 1757806-1757920Exon29: 15 residues, 1758070-1758109Exon30: 62 residues, 1758200-1758380Exon31: 52 residues, 1758478-1758628Exon32: 540 residues, 1758704-1760318Exon33: 2 residues, -Jump to JIP3_HUMAN  
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Loci Cluster (Details)Loci: 2909 387192-390754 ~-4K 13162(NME4)(+)Loci: 2910 415668-512481 ~-97K 13166(RAB11FIP3)(+)Loci: 2911 580179-619272 ~-39K 13173(RAB40C)(+)Loci: 4199 774975-778384 ~-3K 13216(-)Loci: 2912 1143241-1211772 ~-69K 13223(CACNA1H)(+)Loci: 2913 1324663-1339443 ~-15K 13234(BAIAP3)(+)Loci: 4200 1435345-1465013 ~-30K 13244(CLCN7)(-)Loci: 2914 1696221-1760318 ~-64K 13253(MAPK8IP3)(+)Loci: 2915 1979968-1984276 ~-4K 13288(SYNGR3)(+)Loci: 2916 2016896-2028484 ~-12K 13290(SLC9A3R2)(+)Loci: 2917 2038599-2078713 ~-40K 13294(TSC2)(+)Loci: 2918 2138651-2144141 ~-5K 13300(RAB26)(+)Loci: 4201 2167184-2186466 ~-19K 13303(CASKIN1)(-)Loci: 4198 357394-360541 ~-3K 13159(MRPL28)(-)Link out to UCSC