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0JIP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameMAPK8IP1
DescriptionC-jun-amino-terminal kinase interacting protein 1 (jnk-interacting protein 1) (jip-1) (jnk map kinase scaffold protein 1) (islet-brain-1) (ib-1) (mitogen-activated protein kinase 8-interacting protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (IEP)
0019894 kinesin binding (IPI)
0005078 MAP-kinase scaffold activity (IPI)
0005515 protein binding (IPI)
0019901 protein kinase binding (IPI)
0004860 protein kinase inhibitor activity (TAS)
0046328 regulation of JNK cascade (ISS)
0016192 vesicle-mediated transport (ISS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain. 7-stranded beta-sandwich.apped by a C-terminal helix.However.he PI domain contains an additional short N-terminal helix and alarge insertion between strands 1 and 2.hich forms a helix and 2 longconnecting loops. The substrate peptide fits into a surface cleft formedfrom the C-terminal helix and strand 5 .
  IPR006020:Phosphotyrosine interaction region
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling proteins.here they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C delta-1.eta-spectrin.ynamin.on-of-sevenless.rp1.nc-89.app1 and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
IPR006020:PID 
Evalue:-51.0809211730957 
Location:567-701IPR001452:SH3 
Evalue:-10.602059991328 
Location:491-548
SequencesProtein: JIP1_HUMAN (711 aa)
mRNA: NM_005456
Local Annotation
Synapse Ontology
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK04434
  Level 3 annotation:
    mitogen-activated protein kinase 8 interacting protein 1
  Level 2 annotation:
    MAPK signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 91 residues, 45863777-45864048Exon2: 37 residues, 45876211-45876317Exon3: 107 residues, 45878264-45878579Exon4: 29 residues, 45880106-45880188Exon5: 273 residues, 45880498-45881311Exon6: 27 residues, 45881491-45881567Exon7: 59 residues, 45882115-45882288Exon8: 38 residues, 45882581-45882691Exon9: 41 residues, 45882844-45882961Exon10: 25 residues, 45883097-45883168Exon11: 35 residues, 45883277-45883376Exon12: 274 residues, 45883775-45884591Exon13: 2 residues, -Jump to JIP1_HUMAN  
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Loci Cluster (Details)Loci: 2662 45863777-45884591 ~-21K 6614(MAPK8IP1)(+)Loci: 2663 46323559-46358680 ~-35K 6625(+)Loci: 3947 46363215-46364683 ~-1K 6632(CHRM4)(-)Loci: 2661 45825604-45861372 ~-36K 6612(+)Link out to UCSC