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0ITF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTCF4
DescriptionTranscription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005515 protein binding (IPI)
0003702 RNA polymerase II transcription factor acti... (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation . They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development . The bHLH proteins can be classified into discrete categories. One such subdivision according to dimerisation.NA binding and expression characteristics defines seven groups . Class I proteins form dimers within the group or with class II proteins. Class II can only form heterodimers with class I factors. Class III factors are characterised by the presence of a leucine zipper () adjacent to the bHLH domain. Class IV factors may form homodimers or teterodimers with class III proteins. Class V and class VI proteins act as regulators of class I and class II factors and class VII proteins have a PAS domain ().
  IPR001092:Basic helix-loop-helix dimerisation region bHLH
The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundleof four helices in a left-handed twist with two crossover connections. TheHLH domain directs dimerisation.nd is juxtaposed to basic regions tocreate a DNA interaction interface surface that recognises specific DNAsequences. Basic region/HLH (bHLH) proteins regulate diverse biologicalpathways . bHLH proteins include MyoD .REBPs (sterol regulatory element binding proteins).nd yeast Pho4 (phosphatase system) .In certain proteins the bHLH domain contains a leucine-zipper motif. ThebHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a networkof proteins and determines sequence-specific DNA binding . bHLHZip domains occur in the transcription factors Myc.ad.ax and Usf . This entry is bHLHZip.hich covers the bHLH domain and the leucine zipper motif.hen present.
  IPR011598:Helix-loop-helix DNA-binding
Homeodomain proteins are transcription factors that share a related DNA binding homeodomain . The homeodomain was first identified in a number of Drosophila homeotic and segmentation proteins.ut is now known to be well conserved in many other animals.ncluding vertebrates. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha-helices.hich make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions.hich occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. Many proteins contain homeodomains.ncluding Drosophila Engrailed.east mating type proteins.epatocyte nuclear factor 1a and HOX proteins.The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins.ncluding recombinases.yb proteins.ARP response regulators.uman telomeric proteins (hTRF1).aired domain proteins (PAX).east RAP1.entromere-binding proteins CENP-B and ABP-1.ranscriptional regulators (TyrR).raC-type transcriptional activators.nd tetracycline repressor-like proteins (TetR.acR.cdC) .
  IPR009057:Homeodomain-like
IPR001092:HLH 
Evalue:-13.6989698410034 
Location:565-618
SequencesProtein: ITF2_HUMAN (667 aa)
mRNA: BC031056 NM_003199
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 98 residues, 51045966-51046259Exon2: 49 residues, 51046449-51046590Exon3: 78 residues, 51047075-51047305Exon4: 52 residues, 51050749-51050900Exon5: 47 residues, 51052776-51052912Exon6: 70 residues, 51072725-51072929Exon7: 27 residues, 51075543-51075620Exon8: 28 residues, 51078177-51078256Exon9: 24 residues, 51079694-51079762Exon10: 46 residues, 51088059-51088192Exon11: 46 residues, 51093847-51093981Exon12: 37 residues, 51097779-51097885Exon13: 18 residues, 51168587-51168637Exon14: 45 residues, 51169102-51169232Exon15: 23 residues, 51221682-51221747Exon16: 34 residues, 51279247-51279344Exon17: 22 residues, 51282304-51282366Exon18: 26 residues, 51403508-51403581Exon19: 32 residues, 51405273-51405365Exon20: 60 residues, 51406266-51406441Exon21: 2 residues, -Jump to ITF2_HUMANExon1: 32 residues, 51046165-51046259Exon2: 49 residues, 51046449-51046590Exon3: 78 residues, 51047075-51047305Exon4: 56 residues, 51050737-51050900Exon5: 47 residues, 51052776-51052912Exon6: 70 residues, 51072725-51072929Exon7: 27 residues, 51075543-51075620Exon8: 28 residues, 51078177-51078256Exon9: 24 residues, 51079694-51079762Exon10: 46 residues, 51088059-51088192Exon11: 46 residues, 51093847-51093981Exon12: 37 residues, 51097779-51097885Exon13: 18 residues, 51168587-51168637Exon14: 45 residues, 51169102-51169232Exon15: 23 residues, 51221682-51221747Exon16: 34 residues, 51279247-51279344Exon17: 22 residues, 51282304-51282366Exon18: 26 residues, 51403508-51403581Exon19: 32 residues, 51405273-51405365Exon20: 32 residues, 51449526-51449617Exon21: 86 residues, 51453931-51454183Exon22: 2 residues, -Jump to ITF2_HUMAN  
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