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0IRK15_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKCNJ15
DescriptionAtp-sensitive inward rectifier potassium channel 15 (potassium channel, inwardly rectifying subfamily j member 15) (inward rectifier k(+) channel kir4.2) (kir1.3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005242 inward rectifier potassium channel activity (TAS)
0006813 potassium ion transport (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Inwardly-rectifying K+ channels (Kir) are the principal class of two-TM domain K+ channels. They are characterised by the property of inward-rectification.hich is described as the ability to allow large inward currents and smaller outward currents. Inwardly rectifying potassium channels (Kir) are responsible for regulating diverse processes including: cellular excitability.ascular tone.eart rate.enal salt flow.nd insulin release . To date.round twenty members of this superfamily have been cloned.hich can be grouped into six families by sequence similarity.nd these are designated Kir1.x-6.x . Cloned Kir channel cDNAs encode proteins of between ~370-500 residues.oth N- and C-termini are thought to be cytoplasmic.nd the N-terminus lacks a signal sequence. Kir channel alpha subunits possess only 2TM domains linked with a P-domain. Thus.ir channels share similarity with the fifth and sixth domains.nd P-domain of the other families. It is thought that four Kir subunits assemble to form a tetrameric channel complex.hich may be hetero- or homomeric .Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR013521:K+ channel, inward rectifier, conserved region 2
Inwardly-rectifying K+ channels (Kir) are the principal class of two-TM domain K+ channels. They are characterised by the property of inward-rectification.hich is described as the ability to allow large inward currents and smaller outward currents. Inwardly rectifying potassium channels (Kir) are responsible for regulating diverse processes including: cellular excitability.ascular tone.eart rate.enal salt flow.nd insulin release . To date.round twenty members of this superfamily have been cloned.hich can be grouped into six families by sequence similarity.nd these are designated Kir1.x-6.x . Cloned Kir channel cDNAs encode proteins of between ~370-500 residues.oth N- and C-termini are thought to be cytoplasmic.nd the N-terminus lacks a signal sequence. Kir channel alpha subunits possess only 2TM domains linked with a P-domain. Thus.ir channels share similarity with the fifth and sixth domains.nd P-domain of the other families. It is thought that four Kir subunits assemble to form a tetrameric channel complex.hich may be hetero- or homomeric .Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR001838:K+ channel, inward rectifier
Inwardly-rectifying K+ channels (Kir) are the principal class of two-TM domain K+ channels. They are characterised by the property of inward-rectification.hich is described as the ability to allow large inward currents and smaller outward currents. Inwardly rectifying potassium channels (Kir) are responsible for regulating diverse processes including: cellular excitability.ascular tone.eart rate.enal salt flow.nd insulin release . To date.round twenty members of this superfamily have been cloned.hich can be grouped into six families by sequence similarity.nd these are designated Kir1.x-6.x . Cloned Kir channel cDNAs encode proteins of between ~370-500 residues.oth N- and C-termini are thought to be cytoplasmic.nd the N-terminus lacks a signal sequence. Kir channel alpha subunits possess only 2TM domains linked with a P-domain. Thus.ir channels share similarity with the fifth and sixth domains.nd P-domain of the other families. It is thought that four Kir subunits assemble to form a tetrameric channel complex.hich may be hetero- or homomeric .Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.Kir1.3 (also known as Kir4.2) was cloned from human kidney.here it appears to be found most abundantly. At lower levels.t has also been detected in the pancreas and lung. It is most closely related to Kir1.2.o which it is 62% identical. Unlike the other Kir1.x family members.n the Kir1.3 sequence.he Walker Type A consensus motif (for nucleotide binding) is not conserved. Heterologous expression of Kir1.3 in Xenopus oocytes did not lead to detectable channel activity. Indeed.o-expression of Kir1.3 with either Kir1.1 or Kir1.2 reduced currents resulting from expression of these inward rectifier subunits alone.onsistent with a dominant negativeinfluence of Kir1.3 on Kir1.1 and Kir1.2 expression .
  IPR003270:Kir1.3 inward rectifier K+ channel
Inwardly-rectifying K+ channels (Kir) are the principal class of two-TM domain K+ channels. They are characterised by the property of inward-rectification.hich is described as the ability to allow large inward currents and smaller outward currents. Inwardly rectifying potassium channels (Kir) are responsible for regulating diverse processes including: cellular excitability.ascular tone.eart rate.enal salt flow.nd insulin release . To date.round twenty members of this superfamily have been cloned.hich can be grouped into six families by sequence similarity.nd these are designated Kir1.x-6.x . Cloned Kir channel cDNAs encode proteins of between ~370-500 residues.oth N- and C-termini are thought to be cytoplasmic.nd the N-terminus lacks a signal sequence. Kir channel alpha subunits possess only 2TM domains linked with a P-domain. Thus.ir channels share similarity with the fifth and sixth domains.nd P-domain of the other families. It is thought that four Kir subunits assemble to form a tetrameric channel complex.hich may be hetero- or homomeric .Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential.nd in neuronal excitability and plasticity . The potassium channel family iscomposed of several functionally distinct isoforms.hich can be broadlyseparated into 2 groups : the practically non-inactivating delayed group and the rapidly inactivating transient group.These are all highly similar proteins.ith only small amino acidchanges causing the diversity of the voltage-dependent gating mechanism.hannel conductance and toxin binding properties. Each type of K+ channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter.ogether with intracellular kinases; and others are regulated by GTP-binding proteins orother second messengers . In eukaryotic cells.+ channelsare involved in neural signalling and generation of the cardiac rhythm.ct as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes . In prokaryotic cells.hey play a role in themaintenance of ionic homeostasis . All K+ channels discovered so far possess a core of alpha subunits.ach comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG).hich hasbeen termed the K+ selectivity sequence.In families that contain one P-domain.our subunits assemble to form a selective pathway for K+ across the membrane.However.t remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+ channels; and three types of calcium (Ca)-activated K+ channels (BK.K and SK). The 2TM domain family comprises inward-rectifying K+ channels. In addition.here are K+ channel alpha-subunits that possess two P-domains. These are usually highly regulated K+ selective leak channels.
  IPR013518:K+ channel, inward rectifier, conserved region 1
IPR013521:IRK 
Evalue:-226 
Location:30-365IPR003270:KIR13CHANNEL 
Evalue:0 
Location:1-10IPR003270:KIR13CHANNEL 
Evalue:0 
Location:15-24
SequencesProtein: IRK15_HUMAN (375 aa)
mRNA: NM_170736
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
?
sdb:0297 NMDA receptor  (Evidence:keywords)
KO assignmentK05008
  Level 3 annotation:
    potassium inwardly-rectifying channel, subfamily J, member 15
  Level 2 annotation:
    Ion channels
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 80 residues, 38550739-38550977Exon2: 34 residues, 38590717-38590815Exon3: 861 residues, 38593035-38595614Exon4: 2 residues, -Jump to IRK15_HUMAN  
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