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0IQGA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameIQGAP1
DescriptionRas gtpase-activating-like protein iqgap1 (p195).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005884 actin filament (TAS)
0005516 calmodulin binding (TAS)
0005096 GTPase activator activity (TAS)
0005095 GTPase inhibitor activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP . This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as GAP or GTPase-activating proteins . As it is the GTP bound form of ras which is active.hese proteins are said to be down-regulators of ras.The Ras GTPase-activating proteins are quite large (from 765 residues for sar1 to 3079 residues for IRA2) but share only a limited (about 250 residues) region of sequence similarity.eferred to as the catalytic domain or rasGAP domain.Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference ) that do not share sequence similarity with ras GAPs.
  IPR001936:Ras GTPase-activating protein
Ras GTPase-activating protein (rasGAP) is a major contributor to the downregulation of ras by facilitating GTP hydrolysis of activated ras. In addition.AP participates in the down-stream effector system of the ras signaling pathway. Abnormal signal transduction involving activated ras genes plays a major role in the development of a variety of tumors. Depending on the precise genetic alteration.ts location within the gene and the effects it exerts on protein function.asGAP can theoretically function as either an oncogene or as a tumor suppressor gene .
  IPR000593:RasGAP protein, C-terminal
The calponin homology domain (also known as CH-domain) is a superfamily of actin-binding domains found in both cytoskeletal proteins and signal transduction proteins . It comprises the following groups of actin-binding domains:Actinin-type (including spectrin.imbrin.BP-280) (see ).Calponin-type (see ).A comprehensive review of proteins containing this type of actin-binding domains is given in .The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity . Most proteins have two copies of the CH domain.owever some proteins such as calponin and the human vav proto-oncogene () have only a single copy. The structure of an example CH-domain has recently been solved .
  IPR001715:Calponin-like actin-binding
Synonym(s): Rsp5 or WWP domainThe WW domain is a short conserved region in a number ofunrelated proteins.hich folds as a stable.riple stranded beta-sheet.This short domain of approximately 40 amino acids.ay be repeated up to four times in some proteins . The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date.s well as that of aconserved Pro. The WW domain binds to proteins withparticular proline-motifs.AP]-P-P-[AP]-Y.nd/or phosphoserine- phosphothreonine-containing motifs . It is frequently associated with other domains typical for proteins insignal transduction processes.A large variety of proteins containing the WW domain are known. These include; dystrophin. multidomain cytoskeletal protein; utrophin. dystrophin-like protein of unknownfunction; vertebrate YAP protein.ubstrate of an unknown serine kinase; mouse NEDD-4.nvolved in the embryonic development and differentiation of the central nervous system;yeast RSP5.imilar to NEDD-4 in its molecular organization; rat FE65. transcription-factor activator expressed preferentially in liver; tobacco DB10 proteinand others.
  IPR001202:WW/Rsp5/WWP
Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding.ermed18-14 and 1-5-10 based on the position of conserved hydrophobic residues .The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca2+-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains.ccounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule .
  IPR000048:IQ calmodulin-binding region
Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho.ac and/or Cdc42.nactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008936:Rho GTPase activation protein
Ras GTPase-activating protein (rasGAP) is a major contributor to the down regulation of ras by facilitating GTP hydrolysis of activated ras. In addition.AP participates in the down-stream effector system of the ras signalling pathway. Abnormal signal transduction involving activated ras genes plays a major role in the development of a variety of tumours. Depending on the precise genetic alteration.ts location within the gene and the effects it exerts on protein function.asGAP can theoretically function as either an oncogene or as a tumour suppressor gene .
  IPR011575:RasGAP
IPR001936:RasGAP 
Evalue:-121.008773803711 
Location:1025-1237IPR000593:RasGAP_C 
Evalue:-61.6197891235352 
Location:1451-1583IPR001715:CH 
Evalue:-19.6777807052661 
Location:46-155IPR000048:IQ 
Evalue:-4.69896984100342 
Location:776-796IPR001202:WW 
Evalue:-4.52287864685059 
Location:681-710IPR000048:IQ 
Evalue:-4.09690999984741 
Location:806-826IPR000048:IQ 
Evalue:-4 
Location:746-766IPR000048:IQ 
Evalue:-1.69896996021271 
Location:836-856
SequencesProtein: IQGA1_HUMAN (1657 aa)
mRNA: NM_003870
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK05767
  Level 3 annotation:
    IQ motif containing GTPase activating protein
  Level 2 annotation:
    Regulation of actin cytoskeleton
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 53 residues, 88732476-88732632Exon2: 35 residues, 88735009-88735109Exon3: 54 residues, 88770345-88770502Exon4: 28 residues, 88773824-88773902Exon5: 27 residues, 88777954-88778031Exon6: 24 residues, 88783567-88783635Exon7: 40 residues, 88784737-88784851Exon8: 61 residues, 88785741-88785920Exon9: 30 residues, 88787629-88787714Exon10: 56 residues, 88792808-88792972Exon11: 30 residues, 88793794-88793879Exon12: 56 residues, 88797010-88797174Exon13: 55 residues, 88797367-88797528Exon14: 43 residues, 88798663-88798788Exon15: 56 residues, 88800387-88800551Exon16: 32 residues, 88810236-88810327Exon17: 58 residues, 88810504-88810672Exon18: 49 residues, 88811685-88811828Exon19: 59 residues, 88817075-88817246Exon20: 30 residues, 88817950-88818034Exon21: 26 residues, 88818131-88818203Exon22: 25 residues, 88818299-88818369Exon23: 71 residues, 88818720-88818929Exon24: 54 residues, 88820898-88821054Exon25: 56 residues, 88821302-88821466Exon26: 77 residues, 88821900-88822125Exon27: 49 residues, 88826195-88826336Exon28: 30 residues, 88826432-88826517Exon29: 79 residues, 88827596-88827829Exon30: 46 residues, 88828455-88828588Exon31: 36 residues, 88830265-88830368Exon32: 47 residues, 88831189-88831325Exon33: 31 residues, 88831730-88831818Exon34: 73 residues, 88835568-88835781Exon35: 57 residues, 88836780-88836947Exon36: 43 residues, 88838948-88839071Exon37: 38 residues, 88841467-88841576Exon38: 751 residues, 88844230-88846479Exon39: 2 residues, -Jump to IQGA1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4193 88008602-88023595 ~-15K 12995(PLIN)(-)Loci: 4194 88129129-88150938 ~-22K 13000(ANPEP)(-)Loci: 4195 88177792-88238206 ~-60K 13001(AP3S2)(-)Loci: 2905 88609898-88616447 ~-7K 13015(+)Loci: 4196 88691822-88693673 ~-2K 13016(GABARAPL3)(-)Loci: 2906 88732476-88846479 ~-114K 13020(IQGAP1)(+)Loci: 4192 87660562-87679030 ~-18K 12989(POLG)(-)Link out to UCSC