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0IPYR2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPA2
DescriptionInorganic pyrophosphatase 2, mitochondrial precursor (ec 3.6.1.1) (ppase 2) (pyrophosphatase sid6-306).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Inorganic pyrophosphatase () (PPase) .s the enzyme responsible for the hydrolysis of pyrophosphate (PPi) which is formed principally as the product of the many biosynthetic reactions that utilize ATP. All known PPases require the presence of divalent metal cations.ith magnesium conferring the highest activity. Among other residues. lysine has been postulated to be part of or close to the active site. PPases have been sequenced from bacteria such as Escherichia coli (homohexamer).hermophilic bacteria PS-3 and Thermus thermophilus.rom the archaebacteria Thermoplasma acidophilum.rom fungi (homodimer).rom a plant.nd from bovine retina. In yeast. mitochondrial isoform of PPase has been characterized which seems to be involved in energy production and whose activity is stimulated by uncouplers of ATP synthesis.The sequences of PPases share some regions of similarities.mong which is a region that contains three conserved aspartates that are involved in the binding of cations.
  IPR008162:Inorganic pyrophosphatase
IPR008162:Pyrophosphatase 
Evalue:-107.387214660645 
Location:93-277
SequencesProtein: IPYR2_HUMAN (334 aa)
mRNA: NM_176869
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK01507
  Level 3 annotation:
    inorganic pyrophosphatase
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 226 residues, 106509683-106510359Exon2: 14 residues, 106511442-106511479Exon3: 25 residues, 106527172-106527242Exon4: 30 residues, 106536854-106536940Exon5: 44 residues, 106539642-106539770Exon6: 44 residues, 106564801-106564928Exon7: 31 residues, 106578555-106578642Exon8: 42 residues, 106586988-106587108Exon9: 20 residues, 106589955-106590009Exon10: 17 residues, 106594203-106594248Exon11: 23 residues, 106597286-106597351Exon12: 61 residues, 106614499-106614676Exon13: 2 residues, -Jump to IPYR2_HUMAN  
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