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0IPPD_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePPP1R1B
DescriptionDopamine- and camp-regulated neuronal phosphoprotein (darpp-32).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (NAS)
0004860 protein kinase inhibitor activity (TAS)
0004864 protein phosphatase inhibitor activity (TAS)
0007165 signal transduction (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1 . It has been demonstrated that DARPP-32.f phosphorylated.an inhibit protein-phosphatase-1 . DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors.on channels and other physiological factors including the brains response to drugs of abuse.uch as cocaine.piates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate.cting through the N-methyl-d-aspartate receptor.enders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers .
  IPR008466:Protein phosphatase inhibitor, 1DARPP-32
IPR008466:DARPP-32 
Evalue:-2.02227640151978 
Location:1-154
SequencesProtein: IPPD_HUMAN (204 aa)
mRNA: CR606470 NM_032192
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords,domains)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:keywords,domains)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords,domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 183 residues, 35036704-35037252Exon2: 22 residues, 35038948-35039009Exon3: 9 residues, 35039318-35039341Exon4: 27 residues, 35039750-35039826Exon5: 70 residues, 35043661-35043865Exon6: 42 residues, 35045385-35045505Exon7: 271 residues, 35045594-35046401Exon8: 2 residues, -Jump to IPPD_HUMANExon1: 161 residues, 35036771-35037252Exon2: 22 residues, 35038948-35039009Exon3: 11 residues, 35039318-35039345Exon4: 37 residues, 35039721-35039826Exon5: 70 residues, 35043661-35043865Exon6: 42 residues, 35045385-35045505Exon7: 262 residues, 35045594-35046375Exon8: 2 residues, -Jump to IPPD_HUMAN  
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Loci Cluster (Details)Loci: 3000 35036704-35046401 ~-10K 15710(PPP1R1B)(+)Loci: 3001 35046937-35073248 ~-26K 15714(STARD3)(+)Loci: 4284 34583234-34607427 ~-24K 15696(CACNB1)(-)Link out to UCSC