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0IPP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionProtein phosphatase inhibitor 1 (ipp-1) (i-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004865 type 1 serine/threonine specific protein ph... (TAS)
Domain Architecture (Details)
InterPro domains assigned to SynO:
This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1 . It has been demonstrated that DARPP-32.f inhibit protein-phosphatase-1 . DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors.on channels and other physiological factors including the brains response to drugs of abuse.uch as cocaine.piates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate.cting through the N-methyl-d-aspartate receptor.enders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers .
  IPR008466:Protein phosphatase inhibitor, 1DARPP-32
SequencesProtein: IPP1_HUMAN (171 aa)
mRNA: NM_006741
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:domains)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 382 residues, 53259299-53260443Exon2: 37 residues, 53260994-53261101Exon3: 54 residues, 53262026-53262182Exon4: 23 residues, 53262782-53262846Exon5: 14 residues, 53263261-53263299Exon6: 22 residues, 53264310-53264371Exon7: 86 residues, 53268455-53268707Exon8: 2 residues, -Jump to IPP1_HUMAN  
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Loci Cluster (Details)Loci: 4049 53259299-53268707 ~-9K 9014(PPP1R1A)(-)Loci: 2762 53005177-53031900 ~-27K 9004(COPZ1)(+)Link out to UCSC