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0INHA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameINHA
DescriptionInhibin alpha chain precursor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005576 extracellular region (TAS)
0017106 activin inhibitor activity (TAS)
0005125 cytokine activity (TAS)
0008083 growth factor activity (TAS)
0005179 hormone activity (TAS)
0005515 protein binding (IPI)
0007050 cell cycle arrest (TAS)
0030154 cell differentiation (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0007267 cell-cell signaling (TAS)
0030218 erythrocyte differentiation (NAS)
0042541 hemoglobin biosynthesis (IDA)
0006917 induction of apoptosis (IDA)
0045578 negative regulation of B cell differentiation (TAS)
0046882 negative regulation of follicle-stimulating... (NAS)
0045077 negative regulation of interferon-gamma bio... (TAS)
0045650 negative regulation of macrophage different... (TAS)
0042326 negative regulation of phosphorylation (TAS)
0007399 neurogenesis (NAS)
0001541 ovarian follicle development (NAS)
0046881 positive regulation of follicle-stimulating... (TAS)
0009605 response to external stimulus (TAS)
0001501 skeletal development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation.ifferentiation and other functions in many cell types. TGF-beta-1 is a peptide of 112 amino acid residues derived by proteolytic cleavage from the C-terminal of a precursor protein.A number of proteins are known to be related to TGF-beta-1 . Proteins from the TGF-beta family are only active as homo- or heterodimer; the two chains being linked by a single disulphide bond. From X-ray studies of TGF-beta-2 .t is known that all the other cysteines are involved in intrachain disulphide bonds. As shown in the following schematic representation.here are four disulphide bonds in the TGF-betas and in inhibin beta chains.hile the other members of this family lack the first bond.
  IPR001839:Transforming growth factor beta
Inhibins and activins are glycoproteins.ecreted by the gonads.hat belong to the transforming growth factor beta family . They participate in differentiation and growth of diverse cell types. Inhibin inhibits secretion of follicle-stimulating hormone by the pituitary . Inhibin has two isoforms. and B.ith the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits.nhibin B is a dimer of alpha and beta B subunits. Activin A is a dimer of beta A subunits.ctivin AB is a dimer of beta A and beta B chains. Follistatin is bound to inhibin and activin and indirectly modulates the FSH release. In turn.SH stimulates inhibin gene expression in the ovarian follicle .robably mediated by cAMP . The serum levels of inhibin.ctivin.nd follistatin are elevated in pregnant women and decrease after delivery. . Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues.
  IPR002405:Inhibin, alpha subunit
IPR001839:TGF_beta 
Evalue:-35.4202156066895 
Location:259-366IPR002405:INHIBINA 
Evalue:0 
Location:109-133IPR002405:INHIBINA 
Evalue:0 
Location:205-222IPR002405:INHIBINA 
Evalue:0 
Location:187-203
SequencesProtein: INHA_HUMAN (366 aa)
mRNA: NM_002191
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK05500
  Level 3 annotation:
    inhibin, alpha
  Level 2 annotation:
    Cytokines
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 138 residues, 220145197-220145608Exon2: 339 residues, 220147659-220148671Exon3: 2 residues, -Jump to INHA_HUMAN  
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Loci Cluster (Details)Loci: 3213 219232701-219236409 ~-4K 22084(BCS1L)(+)Loci: 3214 219354948-219388259 ~-33K 22089(CYP27A1)(+)Loci: 3215 219532641-219535120 ~-2K 22095(CDK5R2)(+)Loci: 4494 219782737-219791916 ~-9K 22116(ABCB6)(-)Loci: 3216 219991342-219999703 ~-8K 22140(DES)(+)Loci: 3217 220087295-220111732 ~-24K 22148(ACCN4)(+)Loci: 3218 220145197-220148671 ~-3K 22154(INHA)(+)Loci: 4493 219210885-219232599 ~-22K 22082(ZNF142)(-)Link out to UCSC