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0IMB1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionImportin beta-1 subunit (karyopherin beta-1 subunit) (nuclear factor p97) (importin 90).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005643 nuclear pore (TAS)
0008139 nuclear localization sequence binding (TAS)
0005515 protein binding (IPI)
0008270 zinc ion binding (TAS)
0006607 NLS-bearing substrate-nucleus import (TAS)
0000060 protein-nucleus import, translocation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
The exchange of macromolecules between the nucleus and cytoplasm takes place through nuclear pore complexes. Active transport of large molecules through these pore complexes require carrier proteins that shuttle between the two components. Members of the importin-beta/karyopherin-beta family subunits act as carriers for many nuclear trafficking processes . Importin-beta binds cargo in the cytoplasm.he complex moves through the pore and cargo is released in the nucleus on binding of Ran-GTP to importin-beta. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats.ach formed from a pair of alpha-helices. Many nuclear pore proteins contain FG sequence repeats.nd interactions between repeats containing FxFG or GLFG cores and transport factors have been demonstrated. The crystal structure of residues 1-442 of importin-beta bound to a GLFG peptide indicates that this repeat core binds to the same primary site as FxFG cores.uggesting that functional differences between different repeats probably arise from differences in their spatial organization.
  IPR001494:Importin-beta, N-terminal
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes.ncluding intracellular signalling and cytoskeletal regulation.nd include such proteins as beta-catenin.he junctional plaque protein plakoglobin.he adenomatous polyposis coli (APC) tumour suppressor protein.nd the nuclear transport factor importin-alpha.mongst others . A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants.ome Arm-repeat proteins function in intracellular signalling like their mammalian counterparts.hile others have novel functions .The 3-dimensional fold of an armadillo repeat is known from the crystal structure of the 12 repeats form a superhelix of alpha helices with three helices per unit . The cylindrical structure features a positively charged grove.hich presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
The HEAT repeat is a tandemly repeated.7-47 amino acid long moduleoccurring in a number of cytoplasmic proteins.ncluding the fourname-giving proteins huntingtin.longation factor 3 (EF3).he 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 . Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A .he HEAT repeats consistof pairs of antiparallel alpha helices.s predicted in .
SequencesProtein: IMB1_HUMAN (876 aa)
mRNA: NM_002265
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 126 residues, 43082273-43082649Exon2: 21 residues, 43082750-43082809Exon3: 63 residues, 43085058-43085241Exon4: 69 residues, 43089224-43089425Exon5: 53 residues, 43090872-43091025Exon6: 22 residues, 43093483-43093543Exon7: 32 residues, 43095453-43095543Exon8: 39 residues, 43096523-43096634Exon9: 36 residues, 43097421-43097523Exon10: 77 residues, 43100550-43100775Exon11: 66 residues, 43102042-43102234Exon12: 45 residues, 43103066-43103197Exon13: 51 residues, 43105382-43105530Exon14: 26 residues, 43105854-43105926Exon15: 50 residues, 43107002-43107147Exon16: 29 residues, 43108773-43108856Exon17: 38 residues, 43109384-43109492Exon18: 50 residues, 43110410-43110554Exon19: 37 residues, 43110672-43110778Exon20: 40 residues, 43112384-43112499Exon21: 56 residues, 43112872-43113034Exon22: 413 residues, 43114768-43116003Exon23: 2 residues, -Jump to IMB1_HUMAN  
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Loci Cluster (Details)Loci: 3014 43539918-43555104 ~-15K 16119(SNX11)(+)Loci: 3013 43082273-43116003 ~-34K 16096(KPNB1)(+)Link out to UCSC