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0IMA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameKPNA2
DescriptionImportin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0005654 nucleoplasm (TAS)
0008139 nuclear localization sequence binding (TAS)
0005515 protein binding (IPI)
0006259 DNA metabolism (TAS)
0000085 G2 phase of mitotic cell cycle (TAS)
0000072 M phase specific microtubule process (TAS)
0006607 NLS-bearing substrate-nucleus import (TAS)
0000018 regulation of DNA recombination (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of the importin alpha (karyopherin alpha).mportin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus.hrough the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain .
  IPR002652:Importin alpha-like protein, beta-binding region
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. Animal Arm-repeat proteins function in various processes.ncluding intracellular signalling and cytoskeletal regulation.nd include such proteins as beta-catenin.he junctional plaque protein plakoglobin.he adenomatous polyposis coli (APC) tumour suppressor protein.nd the nuclear transport factor importin-alpha.mongst others . A subset of these proteins is conserved across eukaryotic kingdoms. In higher plants.ome Arm-repeat proteins function in intracellular signalling like their mammalian counterparts.hile others have novel functions .The 3-dimensional fold of an armadillo repeat is known from the crystal structure of beta-catenin.here the 12 repeats form a superhelix of alpha helices with three helices per unit . The cylindrical structure features a positively charged grove.hich presumably interacts with the acidic surfaces of the known interaction partners of beta-catenin.
  IPR000225:Armadillo
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR002652:IBB 
Evalue:-43.4948501586914 
Location:5-99IPR000225:Arm 
Evalue:-12.017728805542 
Location:324-364IPR000225:Arm 
Evalue:-11.8860569000244 
Location:151-191IPR000225:Arm 
Evalue:-9.50863838195801 
Location:366-406IPR000225:Arm 
Evalue:-8.19381999969482 
Location:108-149IPR000225:Arm 
Evalue:-8.08092212677002 
Location:241-280IPR000225:Arm 
Evalue:-7.06048059463501 
Location:409-449IPR000225:Arm 
Evalue:-6.43179845809936 
Location:282-322IPR000225:Arm 
Evalue:-3.29242992401123 
Location:193-238
SequencesProtein: IMA2_HUMAN (529 aa)
mRNA: NM_002266
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 37 residues, 63462309-63462418Exon2: 34 residues, 63463687-63463785Exon3: 48 residues, 63463935-63464073Exon4: 31 residues, 63467255-63467344Exon5: 91 residues, 63468662-63468931Exon6: 33 residues, 63469482-63469577Exon7: 90 residues, 63469677-63469941Exon8: 80 residues, 63470415-63470649Exon9: 63 residues, 63470898-63471081Exon10: 52 residues, 63472349-63472499Exon11: 118 residues, 63473081-63473431Exon12: 2 residues, -Jump to IMA2_HUMANLoci index, Chromosomal location, Length, Possible relational loci clusterExon1: 117 residues, 1713111-1713461Exon2: 52 residues, 1714043-1714193Exon3: 63 residues, 1715461-1715644Exon4: 80 residues, 1715893-1716127Exon5: 90 residues, 1716599-1716863Exon6: 33 residues, 1716963-1717058Exon7: 91 residues, 1717608-1717877Exon8: 31 residues, 1719196-1719285Exon9: 48 residues, 1722467-1722605Exon10: 34 residues, 1722755-1722853Exon11: 38 residues, 1724122-1724231Exon12: 2 residues, -Jump to IMA2_HUMAN