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0IKBB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNFKBIB
DescriptionNf-kappab inhibitor beta (nf-kappa-bib) (i-kappa-b-beta) (ikappabbeta) (ikb-beta) (ikb-b) (thyroid receptor-interacting protein 9) (tr- interacting protein 9).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0004871 signal transducer activity (TAS)
0003713 transcription coactivator activity (TAS)
0007165 signal transduction (TAS)
0006350 transcription (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers . The repeat has been found in proteins of diverse function such as transcriptional initiators.ell-cycle regulators.ytoskeletal.on transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures . Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure .
  IPR002110:Ankyrin
IPR002110:Ank 
Evalue:-7.69896984100342 
Location:240-272IPR002110:Ank 
Evalue:-7.25181198120117 
Location:206-238IPR002110:Ank 
Evalue:-3.72124648094177 
Location:93-125IPR002110:Ank 
Evalue:-3.619788646698 
Location:57-89IPR002110:Ank 
Evalue:-3.12493872642517 
Location:126-148IPR002110:Ank 
Evalue:0.857332468032837 
Location:273-298
SequencesProtein: IKBB_HUMAN (356 aa)
mRNA: NM_002503
Local Annotation
Synapse Ontology
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
KO assignmentK02581
  Level 3 annotation:
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
  Level 2 annotation:
    Adipocytokine signaling pathway
    T cell receptor signaling pathway
    B cell receptor signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 80 residues, 44082454-44082691Exon2: 37 residues, 44087494-44087600Exon3: 113 residues, 44087681-44088015Exon4: 31 residues, 44089700-44089789Exon5: 89 residues, 44089878-44090139Exon6: 56 residues, 44091210-44091373Exon7: 2 residues, -Jump to IKBB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3108 43830166-43913010 ~-83K 18756(ACTN4)(+)Loci: 4387 43953451-43955988 ~-3K 18760(LGALS7)(-)Loci: 3109 43971693-43974232 ~-3K 18761(LGALS7)(+)Loci: 4388 44061041-44082201 ~-21K 18769(SIRT2)(-)Loci: 3110 44082454-44091373 ~-9K 18775(NFKBIB)(+)Loci: 4389 44097746-44113376 ~-16K 18777(SARS2)(-)Loci: 3111 44113187-44115497 ~-2K 18779(MRPS12)(+)Loci: 3112 44308259-44361886 ~-54K 18787(PAK4)(+)Loci: 3107 43616179-43770042 ~-154K 18750(RYR1)(+)Link out to UCSC