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0IDH3A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameIDH3A
DescriptionIsocitrate dehydrogenase subunit alpha, mitochondrial precursor (ec 1.1.1.41) (isocitric dehydrogenase) (nad(+)-specific icdh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005975 carbohydrate metabolism (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Isocitrate dehydrogenase (IDH) .s an important enzyme of carbohydrate metabolism which catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD+ () or on NADP+ (). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent.he other NADP+-dependent).hile the third one (also NADP+-dependent) is cytoplasmic. In Escherichia coli the activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.3-isopropylmalate dehydrogenase () (IMDH) .atalyzes the third step in the biosynthesis of leucine in bacteria and fungi.he oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate.Tartrate dehydrogenase () catalyzes the reduction of tartrate to oxaloglycolate.These enzymes are evolutionary related . The best conserved region of these enzymes is a glycine-rich stretch of residues located in the C-terminal section.
  IPR001804:Isocitrate/isopropylmalate dehydrogenase, dimeric type
Several NAD- or NADP-dependent dehydrogenases.ncluding 3-isopropylmalate dehydrogenase.artrate dehydrogenase.nd the multimeric forms of isocitrate dehydrogenase.hare a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon.ow adjacent to a carbonyl group.eadily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and belog to this group. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH.xcept for the residues involved in cofactor specificity.uch more closely than it resembles other prokaryotic NADP-dependent IDH.ncluding that of Thermus aquaticus strain YT1.
  IPR004434:Isocitrate dehydrogenase NAD-dependent, mitochondrial
Isocitrate dehydrogenase (IDH) .s an important enzyme of carbohydrate metabolism which catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. IDH is either dependent on NAD+ () or on NADP+ (). In eukaryotes there are at least three isozymes of IDH: two are located in the mitochondrial matrix (one NAD+-dependent.he other NADP+-dependent).hile the third one (also NADP+-dependent) is cytoplasmic. In Escherichia coli the activity of a NADP+-dependent form of the enzyme is controlled by the phosphorylation of a serine residue; the phosphorylated form of IDH is completely inactivated.3-isopropylmalate dehydrogenase () (IMDH) .atalyzes the third step in the biosynthesis of leucine in bacteria and fungi.he oxidative decarboxylation of 3-isopropylmalate into 2-oxo-4-methylvalerate. Tartrate dehydrogenase () catalyzes the reduction of tartrate to oxaloglycolate.These enzymes are evolutionary related . The best conserved region of these enzymes is a glycine-rich stretch of residues located in the C-terminal section. This entry includes both dimeric-type IDH.n which the active site is usually located between the two identical subunits.s well as the monomeric-type IDH.
  IPR013814:Isocitrate/isopropylmalate dehydrogenase
IPR001804:Iso_dh 
Evalue:-168.721252441406 
Location:33-358
SequencesProtein: IDH3A_HUMAN (366 aa)
mRNA: CR749548 NM_005530
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00030
  Level 3 annotation:
    isocitrate dehydrogenase (NAD+)
  Level 2 annotation:
    Citrate cycle (TCA cycle)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 19 residues, 76228773-76228827Exon2: 23 residues, 76234609-76234672Exon3: 30 residues, 76236944-76237028Exon4: 40 residues, 76239488-76239603Exon5: 64 residues, 76240977-76241165Exon6: 46 residues, 76241630-76241764Exon7: 36 residues, 76242903-76243006Exon8: 23 residues, 76243112-76243177Exon9: 30 residues, 76244388-76244473Exon10: 53 residues, 76245546-76245699Exon11: 542 residues, 76248318-76249938Exon12: 2 residues, -Jump to IDH3A_HUMANExon1: 18 residues, 76228774-76228827Exon2: 23 residues, 76234609-76234672Exon3: 243 residues, 76236304-76237028Exon4: 40 residues, 76239488-76239603Exon5: 64 residues, 76240977-76241165Exon6: 55 residues, 76241605-76241764Exon7: 36 residues, 76242903-76243006Exon8: 23 residues, 76243112-76243177Exon9: 30 residues, 76244388-76244473Exon10: 53 residues, 76245546-76245699Exon11: 250 residues, 76248318-76249064Exon12: 2 residues, -Jump to IDH3A_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2903 76644960-76673513 ~-29K 12833(CHRNA5)(+)Loci: 4183 76672451-76700692 ~-28K 12834(-)Loci: 4184 76703690-76720642 ~-17K 12836(CHRNB4)(-)Loci: 4185 77041340-77169895 ~-129K 12842(RASGRF1)(-)Loci: 2902 76228773-76249938 ~-21K 12813(IDH3A)(+)Link out to UCSC