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0ID3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameID3
DescriptionDna-binding protein inhibitor id-3 (inhibitor of dna binding 3) (id- like protein inhibitor hlh 1r21) (helix-loop-helix protein heir-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003714 transcription corepressor activity (TAS)
0007275 development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Basic helix-loop-helix proteins (bHLH) are a group of eukaryotic transcription factors that exert a determinative influence in a variety of developmental pathways. These transcription factors are characterised by a highly evolutionary conserved bHLH domain that mediates specific dimerisation . They facilitate the conversion of inactive monomers to trans-activating dimers at appropriate stages of development . The bHLH proteins can be classified into discrete categories. One such subdivision according to dimerisation.NA binding and expression characteristics defines seven groups . Class I proteins form dimers within the group or with class II proteins. Class II can only form heterodimers with class I factors. Class III factors are characterised by the presence of a leucine zipper () adjacent to the bHLH domain. Class IV factors may form homodimers or teterodimers with class III proteins. Class V and class VI proteins act as regulators of class I and class II factors and class VII proteins have a PAS domain ().
  IPR001092:Basic helix-loop-helix dimerisation region bHLH
The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundleof four helices in a left-handed twist with two crossover connections. TheHLH domain directs dimerisation.nd is juxtaposed to basic regions tocreate a DNA interaction interface surface that recognises specific DNAsequences. Basic region/HLH (bHLH) proteins regulate diverse biologicalpathways . bHLH proteins include MyoD .REBPs (sterol regulatory element binding proteins).nd yeast Pho4 (phosphatase system) .In certain proteins the bHLH domain contains a leucine-zipper motif. ThebHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a networkof proteins and determines sequence-specific DNA binding . bHLHZip domains occur in the transcription factors Myc.ad.ax and Usf . This entry is bHLHZip.hich covers the bHLH domain and the leucine zipper motif.hen present.
  IPR011598:Helix-loop-helix DNA-binding
IPR001092:HLH 
Evalue:-8.95860731484177 
Location:32-86
SequencesProtein: ID3_HUMAN (119 aa)
mRNA: NM_002167
Local Annotation
Synapse Ontology
activation of protein kinase C
sdb:0206 activation of protein kinase C  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 151 residues, 23757042-23757493Exon2: 30 residues, 23758012-23758097Exon3: 224 residues, 23758204-23758872Exon4: 2 residues, -Jump to ID3_HUMAN  
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Loci Cluster (Details)Loci: 3779 23390975-23393809 ~-3K 651(HTR1D)(-)Loci: 3780 23757042-23758872 ~-2K 667(ID3)(-)Loci: 3781 24000954-24024536 ~-24K 680(HMGCL)(-)Loci: 3782 24073047-24112404 ~-39K 686(CNR2)(-)Loci: 3783 24168159-24179408 ~-11K 691(FUSIP1)(-)Loci: 2490 23218532-23282771 ~-64K 646(AOF2)(+)Link out to UCSC