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0IAPP_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionIslet amyloid polypeptide precursor (diabetes-associated peptide) (dap) (amylin) (insulinoma amyloid peptide).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005625 soluble fraction (TAS)
0005102 receptor binding (TAS)
0006915 apoptosis (TAS)
0007267 cell-cell signaling (TAS)
0007165 signal transduction (TAS)

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Domain Architecture (Details)
InterPro domains assigned to SynO:
The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner.roducing either the calcium regulatory hormone CT in the thyroid.r the neuropeptide calcitonin gene related peptide (CGRP) in the brain . In medullary carcinoma of the thyroid.oth peptides are produced .CGRP is a 37-residue peptide produced by alternative splicing of the CT gene. CGRP induces vasodilation in various vessels.ncluding those of the coronary.erebral and systemic vasculature. A neurotransmitter or neuro-modulator role is suggested by its abundance in the CNS . The structure of human CGRP has been determined by 1H NMR . The main conformational feature of the hormone is an N-terminal disulphide-bonded loop (residues 2-7).eading into a well-defined alpha-helix between residues 8 and 18; thereafter.he structure is predominantly disordered.lthough there are indications of a preference for a turn-type conformation between residues 19 and 21 .
  IPR002163:Calcitonin, beta type
InterPro domains unassigned to SynO:
Calcitonin is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood.y promoting the incorporation of these ions in the bones.lpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids.alled calcitonin gene-related peptide (CGRP).eta type. CGRP induces vasodilatation in a variety of vessels.ncluding the coronary.erebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.Islet amyloid polypeptide (IAPP) (also known as diabetes-associated peptide (DAP).r amylin) is a peptide of 37 amino acids that selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle.hile not affecting adipocyte glucose metabolism. Structurally.APP is closely related to CGRP.Two conserved cysteines in the N-terminal of these peptides are known to be involved in a disulphide bond. The C-terminal residue of all three peptides is amidated.
Islet amyloid polypeptide (IAPP) (also known as diabetes-associated peptideor amylin) is a pancreatic islet hormone that is stored with insulin in betacell granules . IAPP has a propensity to form islet cell-disrupting amyloid deposits.nd opposes the action of insulin in peripheral tissues; the peptide may therefore have a significant role in the development of Type2 diabetes mellitus . It is thought that an intrinsic structural motif ofIAPP.hich only occurs in species that develop age-associated or Type 2 diabetes (e.g..umans and cats).s linked to its amyloidogenicity .IAPP is a short.7-residue peptide. The hormone selectively inhibits insulin-stimulated glucose utilisation and glycogen deposition in muscle.ut does not affect adipocyte glucose metabolism. The sequences of amylinand the calcitonin gene-related peptides (CGRPs) show strong similarity:both peptides have a conserved N-terminal intramolecular disulphide bridge.nd both have a C-terminal glycine.hich suggests that the C-terminalresidue of amylin.ike that of CGRP.s amidated .Near- and far-UV CD spectra of human alpha CGRP.nalogues and fragments ofCGRP.nd amylin have been recorded in aqueous solution and in trifluoro-ethanol/water mixtures . The peptides were shown to contain significantamounts of alpha-helix in aqueous solution.his amount increasing upon addition of TFE. Amylin appears to contain less helix than CGRP .
  IPR000443:Islet amyloid protein
SequencesProtein: IAPP_HUMAN (89 aa)
mRNA: NM_000415
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:domains)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 41 residues, 21417084-21417205Exon2: 33 residues, 21417537-21417632Exon3: 417 residues, 21422437-21423683Exon4: 2 residues, -Jump to IAPP_HUMAN  
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