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0HYAL2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHYAL2
DescriptionHyaluronidase 2 precursor (ec 3.2.1.35) (hyal-2) (hyaluronoglucosaminidase 2) (luca-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005764 lysosome (TAS)
0004415 hyalurononglucosaminidase activity (TAS)
0006027 glycosaminoglycan catabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates.r between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosylhydrolases.ased on sequence similarity.as led to the definition of 85 different families . This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site . Because the fold of proteins is better conserved than their sequences.ome of the families can be grouped in clans.Glycoside hydrolase family 56 comprises enzymes with only one known activity; hyaluronidase ().The venom of honeybees contains several biologically-active peptides andtwo enzymes.ne of which is a hyaluronidase . The amino acid sequenceof bee venom hyaluronidase contains 349 amino acids.nd includes fourcysteines and a number of potential glycosylation sites . The sequenceshows a high degree of similarity to PH-20. membrane protein of mammaliansperm involved in sperm-egg adhesion.upporting the view that hyaluronidasesplay a role in fertilisation .PH-20 is required for sperm adhesion to the egg zona pellucida; it islocated on both the sperm plasma membrane and acrosomal membrane . Theamino acid sequence of the mature protein contains 468 amino acids.ndincludes six potential N-linked glycosylation sites and twelve cysteines.ight of which are tightly clustered near the C-terminus .
  IPR001968:Glycoside hydrolase, family 56
Epidermal growth factors and transforming growth factors belong to a general class of proteins that share a repeat pattern involving a number of conserved Cys residues. Growth factors are involved in cell recognition and division . The repeating pattern.specially of cysteines (the so-called EGF repeat).s thought to be important to the 3D structure of the proteins.nd hence its recognition by receptors and other molecules. The type 1 EGF signature includes six conserved cysteines believed to be involved in disulphide bond formation. The EGF motif is found frequently in nature.articularly in extracellular proteins.
  IPR006210:EGF
IPR001968:Glyco_hydro_56 
Evalue:-233.161148071289 
Location:25-363IPR013032:EGF_1 
Evalue:0 
Location:427-438IPR000742:EGF_3 
Evalue:0 
Location:0-0
SequencesProtein: HYAL2_HUMAN (473 aa)
mRNA: NM_033158
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01197
  Level 3 annotation:
    hyaluronoglucosaminidase
  Level 2 annotation:
    Glycosaminoglycan degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 244 residues, 50330243-50330974Exon2: 32 residues, 50331390-50331480Exon3: 324 residues, 50332003-50332970Exon4: 36 residues, 50333800-50333903Exon5: 2 residues, -Jump to HYAL2_HUMAN  
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Loci Cluster (Details)Loci: 4601 48530128-48569231 ~-39K 25651(PFKFB4)(-)Loci: 4602 48611435-48622102 ~-11K 25656(UQCRC1)(-)Loci: 4603 48637834-48684985 ~-47K 25658(CELSR3)(-)Loci: 4604 48686283-48698338 ~-12K 25669(NCKIPSD)(-)Loci: 4605 48762098-48860265 ~-98K 25672(-)Loci: 4606 49133551-49145603 ~-12K 25699(LAMB2)(-)Loci: 4607 49429215-49435016 ~-6K 25713(AMT)(-)Loci: 3354 49566925-49683976 ~-117K 25718(BSN)(+)Loci: 4608 49921309-49942261 ~-21K 25739(-)Loci: 4609 50330243-50333903 ~-4K 25774(HYAL2)(-)Loci: 4600 48420266-48441746 ~-21K 25634(PLXNB1)(-)Link out to UCSC