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0HXK1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionHexokinase type i (ec (hk i) (brain form hexokinase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004396 hexokinase activity (TAS)
0006096 glycolysis (TAS)

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Domain Architecture (Details)
InterPro domains unassigned to SynO:
Hexokinase is an important enzyme that catalyses the ATP-dependent conversion of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). The enzyme can catalyse this reaction on glucose.ructose.orbitol and glucosamine.nd as such is the first step in a number of metabolic pathways . The addition of a phosphate group to the sugar acts to trap it in a cell.ince the negatively charged phosphate cannot easily traverse the plasma membrane.The enzyme is widely distributed in eukaryotes. There are three isozymes of hexokinase in yeast (PI.II and glucokinase): isozymes PI and PII phosphorylate both aldo- and keto-sugars; glucokinase is specific for aldo-hexoses. All three isozymes contain two domains . Structural studies of yeast hexokinase reveal a well-defined catalytic pocket that binds ATP and hexose.llowing easy transfer of the phosphate from ATP to the sugar . Vertebrates contain four hexokinase isozymes.esignated I to types I to III contain a duplication of the two-domain yeast-type hexokinases. Both the N- and C-terminal halves bind hexose and H6P.hough in types I an III only the C-terminal half supports catalysis.hile both halves support catalysis in type II. The N-terminal half is the regulatory region. Type IV hexokinase is similar to the yeast enzyme in containing only the two domains.nd is sometimes incorrectly referred to as glucokinase.The different vertebrate isozymes differ in their catalysis.ocalisation and regulation.hereby contributing to the different patterns of glucose metabolism in different tissues . Whereas types I to III can phosphorylate a variety of hexose sugars and are inhibited by glucose-6-phosphate (G6P).ype IV is specific for glucose and shows no G6P inhibition. Type I enzyme may have a catabolic function.roducing H6P for energy production in glycolysis; it is bound to the mitochondrial membrane.hich enables the coordination of glycolysis with the TCA cycle. Types II and III enzyme may have anabolic functions.roviding H6P for glycogen or lipid synthesis. Type IV enzyme is found in the liver and pancreatic it is controlled by insulin (activation) and glucagon (inhibition). In pancreatic beta-cells.ype IV enzyme acts as a glucose sensor to modify insulin secretion. Mutations in type IV hexokinase have been associated with diabetes mellitus.
SequencesProtein: HXK1_HUMAN (917 aa)
mRNA: NM_000188
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK00844
  Level 3 annotation:
  Level 2 annotation:
    Glycolysis / Gluconeogenesis
    Fructose and mannose metabolism
    Galactose metabolism
    Starch and sucrose metabolism
    Aminosugars metabolism
    Streptomycin biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 49 residues, 70748628-70748772Exon2: 56 residues, 70773588-70773751Exon3: 51 residues, 70789658-70789807Exon4: 42 residues, 70794544-70794664Exon5: 34 residues, 70798297-70798393Exon6: 35 residues, 70798998-70799098Exon7: 63 residues, 70799202-70799386Exon8: 54 residues, 70806695-70806851Exon9: 80 residues, 70809623-70809857Exon10: 103 residues, 70812248-70812553Exon11: 51 residues, 70814094-70814243Exon12: 42 residues, 70814557-70814677Exon13: 34 residues, 70816084-70816180Exon14: 35 residues, 70818958-70819058Exon15: 63 residues, 70821886-70822070Exon16: 54 residues, 70824711-70824867Exon17: 80 residues, 70828356-70828590Exon18: 298 residues, 70830752-70831641Exon19: 2 residues, -Jump to HXK1_HUMAN  
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Loci Cluster (Details)Loci: 2622 70748628-70831641 ~-83K 5039(HK1)(+)Loci: 3897 70834248-70846607 ~-12K 5040(TACR2)(-)Loci: 2621 70553913-70602620 ~-49K 5030(VPS26)(+)Link out to UCSC