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0HS90A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHSPCA
DescriptionHeat shock protein hsp 90-alpha (hsp 86).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005829 cytosol (NAS)
0005524 ATP binding (TAS)
0030235 nitric-oxide synthase regulator activity (ISS)
0000166 nucleotide binding (TAS)
0042803 protein homodimerization activity (TAS)
0030911 TPR domain binding (IDA)
0051082 unfolded protein binding (ISS)
0006839 mitochondrial transport (TAS)
0045429 positive regulation of nitric oxide biosynt... (ISS)
0042026 protein refolding (TAS)
0006986 response to unfolded protein (NAS)
0007165 signal transduction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins (hsp) . The 90 kDa heat shock protein.sp90.s one of the most abundant proteins in eukaryotic cells.omprising 12% of cellular proteins under non-stress conditions . Its contribution to various cellular processes including signal transduction.rotein folding.rotein degradation and morphological evolution has been extensively studied . The full functional activity of Hsp90 is gained in concert with other co-chaperones.laying an important role in the folding of newly synthesised proteins and stabilisation and refolding of denatured proteins after stress. Apart from its co-chaperones.sp90 binds to an array of client proteins.here the co-chaperone requirement varies and depends on the actual client. The sequences of hsp90s show a distinctive domain structure.ith a highly-conserved N-terminal domain separated from a conserved.cidic C-terminal domain by a highly-acidic.lexible linker region.
  IPR001404:Heat shock protein Hsp90
This domain is found in several ATP-binding proteins for example: histidine kinase.NA gyrase B.opoisomerases .eat shock protein HSP90 .hytochrome-like ATPases and DNA mismatch repair proteins.
  IPR003594:ATP-binding region, ATPase-like
IPR003594:HATPase_c 
Evalue:-18.236572265625 
Location:39-192IPR001404:HSP90 
Evalue:-0 
Location:195-731IPR001404:HEATSHOCK90 
Evalue:0 
Location:17-37
SequencesProtein: HS90A_HUMAN (731 aa)
mRNA: AJ890083 NM_001017963
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK04079
  Level 3 annotation:
    molecular chaperone HtpG (Hsp90)
  Level 2 annotation:
    Protein folding and associated processing
    Antigen processing and presentation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 352 residues, 101616858-101617911Exon2: 113 residues, 101618200-101618534Exon3: 91 residues, 101619123-101619392Exon4: 51 residues, 101619635-101619783Exon5: 65 residues, 101619882-101620073Exon6: 57 residues, 101620488-101620654Exon7: 108 residues, 101620770-101621088Exon8: 46 residues, 101621387-101621521Exon9: 124 residues, 101621847-101622214Exon10: 56 residues, 101622306-101622468Exon11: 15 residues, 101623075-101623115Exon12: 2 residues, -Jump to HS90A_HUMANExon1: 258 residues, 101617138-101617911Exon2: 113 residues, 101618200-101618534Exon3: 91 residues, 101619123-101619392Exon4: 51 residues, 101619635-101619783Exon5: 65 residues, 101619882-101620073Exon6: 57 residues, 101620488-101620654Exon7: 108 residues, 101620770-101621088Exon8: 46 residues, 101621387-101621521Exon9: 124 residues, 101621847-101622214Exon10: 56 residues, 101622306-101622468Exon11: 72 residues, 101637964-101638175Exon12: 147 residues, 101675339-101675776Exon13: 2 residues, -Jump to HS90A_HUMAN  
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Loci Cluster (Details)Loci: 4153 101616858-101675776 ~-59K 11788(HSPCA)(-)Loci: 2863 101500736-101586887 ~-86K 11786(DNCH1)(+)Link out to UCSC