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0HRH3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHRH3
DescriptionHistamine h3 receptor (hh3r) (g-protein coupled receptor 97).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004969 histamine receptor activity (TAS)
0007187 G-protein signaling, coupled to cyclic nucl... (TAS)
0007269 neurotransmitter secretion (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Histamine is distributed within mast cells in all peripheral tissues and is a well-characterised mediator of inflammation and allergy . It also regulates release of gastric acid from parietal cells in the gastric mucosa. H3 receptors function as presynaptic autoreceptors on histamine-containing neurones. They are expressed abundantly in the central nervous system.ith highest levels found in the thalamus.audate nucleus and cortex. High levels of expression are also found in the hypothalamus.ippocampus and olfactory tubercle. In the periphery.ow levels of H3 have been detected in the human small intestine.estis and prostate but not in a number of other tissues tested.ncluding the heart.ung and spleen . Binding of histamine to H3 receptors results in inhibition of forskolin-stimulated cAMP accumulation.uggesting coupling to a G-protein of the Gi class .
  IPR003980:Histamine H3 receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
IPR000276:7tm_1 
Evalue:-69.4436950683594 
Location:51-412IPR003980:HISTAMINEH3R 
Evalue:0 
Location:20-38IPR003980:HISTAMINEH3R 
Evalue:0 
Location:1-19
SequencesProtein: HRH3_HUMAN (445 aa)
mRNA: AB045369 NM_007232
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords,domains)
KO assignmentK04151
  Level 3 annotation:
    histamine receptor H3
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 149 residues, 60223411-60223857Exon2: 307 residues, 60224460-60225377Exon3: 57 residues, 60226941-60227108Exon4: 94 residues, 60228171-60228449Exon5: 2 residues, -Jump to HRH3_HUMANExon1: 653 residues, 60223421-60225377Exon2: 57 residues, 60226941-60227108Exon3: 180 residues, 60228171-60228707Exon4: 2 residues, -Jump to HRH3_HUMAN  
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Loci Cluster (Details)Loci: 4536 60317517-60375763 ~-58K 23485(LAMA5)(-)Loci: 4535 60223411-60228707 ~-5K 23475(HRH3)(-)Link out to UCSC