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0HRH1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHRH1
DescriptionHistamine h1 receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0004969 histamine receptor activity (TAS)
0007200 G-protein signaling, coupled to IP3 second ... (TAS)
0006954 inflammatory response (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Histamine is distributed within mast cells in all peripheral tissues andis a well-characterised mediator of inflammation and allergy . It alsoregulates release of gastric acid from parietal cells in the gastricmucosa. H1 receptors mediate increase in vascular permeability inducedby histamine at sites of inflammation. H1 antagonists are used clinicallyin the treatment of allergic and anaphylactic reactions.ariousinflammatory conditions.nd motion sickness. The receptor is distributedwidely in the periphery.otably smooth muscle.here it stimulatescontraction.nd also in the adrenal medulla.ascular endothelium andheart. It is found throughout the CNS.ncluding the cerebral cortex.pinal cord and cerebellum.
  IPR000921:Histamine H1 receptor
IPR000276:7tm_1 
Evalue:-80.4685211181641 
Location:44-468IPR000921:HISTAMINEH1R 
Evalue:0 
Location:469-483
SequencesProtein: HRH1_HUMAN (487 aa)
mRNA: NM_000861
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04149
  Level 3 annotation:
    histamine receptor H1
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 19 residues, 11269399-11269454Exon2: 30 residues, 11269818-11269904Exon3: 1244 residues, 11275688-11279415Exon4: 2 residues, -Jump to HRH1_HUMAN  
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Loci Cluster (Details)Loci: 3333 11009455-11055934 ~-46K 25204(SLC6A1)(+)Loci: 3334 11269399-11279415 ~-10K 25205(HRH1)(+)Loci: 3332 10832916-10955144 ~-122K 25203(SLC6A11)(+)Link out to UCSC