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0HPCL1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionHippocalcin-like protein 1 (visinin-like protein 3) (vilip-3) (calcium-binding protein bdr-1) (hlp2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005509 calcium ion binding (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Recoverin. retinal calcium-binding protein.elongs to the larger family ofproteins which have an EF-hand calcium-binding domain. Recoverinparticipates in the recovery phase of visual excitation and in adaption to light.The Ca2+-bound form of recoverin prolongs the photoresponse.resumably by blockingphosphorylation of photoexcited rhodopsin. Recoverin contains a covalently-attachedmyristoyl group.r acyl group.t its N-terminus.nd two Ca2+-binding sites .A number of other proteins including visinin.ippocalcin.eurocalcin.-modulin.isinin-like protein.nd frequenin belong to this family. All of thefamily memebers have the aromatic residues that contribute to the myristoyl-bindingpocket.
Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1.... and 12; these residues are denoted by X...Y.X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand).
  IPR002048:Calcium-binding EF-hand
This domain consists of a duplication of two EF-hand each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
SequencesProtein: HPCL1_HUMAN (192 aa)
mRNA: CR749837 NM_134421
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 82 residues, 10361276-10361519Exon2: 30 residues, 10454411-10454497Exon3: 59 residues, 10466138-10466311Exon4: 136 residues, 10477310-10477712Exon5: 37 residues, 10480559-10480665Exon6: 299 residues, 10484300-10485193Exon7: 2 residues, -Jump to HPCL1_HUMANExon1: 17 residues, 10381923-10381973Exon2: 57 residues, 10411792-10411958Exon3: 30 residues, 10454411-10454497Exon4: 59 residues, 10466138-10466311Exon5: 136 residues, 10477310-10477712Exon6: 1001 residues, 10480559-10483558Exon7: 94 residues, 10483796-10484072Exon8: 211 residues, 10484300-10484928Exon9: 2 residues, -Jump to HPCL1_HUMAN  
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