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0HOOK2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionHook homolog 2 (h-hook2) (hhk2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006897 endocytosis (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of several HOOK1. and 3 proteins from different eukaryotic organisms. The different members of the Homo sapiens gene family are HOOK1.OOK2 and HOOK3. Different domains have been identified in the three Homo sapiens HOOK proteins.nd it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules.hereas the central coiled-coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes .hereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head .
SequencesProtein: HOOK2_HUMAN (719 aa)
mRNA: NM_013312
Local Annotation
Synapse Ontology
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 144 residues, 12734816-12735245Exon2: 26 residues, 12735341-12735413Exon3: 39 residues, 12735481-12735592Exon4: 36 residues, 12736627-12736731Exon5: 29 residues, 12736812-12736895Exon6: 13 residues, 12737503-12737538Exon7: 4 residues, 12737642-12737648Exon8: 31 residues, 12737740-12737828Exon9: 48 residues, 12737916-12738054Exon10: 25 residues, 12739208-12739278Exon11: 31 residues, 12739629-12739717Exon12: 39 residues, 12739826-12739937Exon13: 69 residues, 12741694-12741896Exon14: 49 residues, 12742745-12742886Exon15: 55 residues, 12742972-12743133Exon16: 29 residues, 12743210-12743291Exon17: 23 residues, 12744003-12744066Exon18: 24 residues, 12744426-12744494Exon19: 46 residues, 12744593-12744726Exon20: 19 residues, 12744807-12744858Exon21: 26 residues, 12746482-12746555Exon22: 30 residues, 12746625-12746711Exon23: 41 residues, 12747218-12747337Exon24: 2 residues, -Jump to HOOK2_HUMAN  
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Loci Cluster (Details)Loci: 4368 12768634-12773694 ~-5K 18105(PRDX2)(-)Loci: 3091 12810347-12846765 ~-36K 18111(MAST1)(+)Loci: 3092 12862973-12871782 ~-9K 18114(GCDH)(+)Loci: 4369 13115902-13122052 ~-6K 18133(STX10)(-)Loci: 4370 13179114-13478317 ~-299K 18136(CACNA1A)(-)Loci: 4367 12734816-12747337 ~-13K 18101(HOOK2)(-)Link out to UCSC