SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0HOME3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHOMER3
DescriptionHomer protein homolog 3 (homer-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (NAS)
0007216 metabotropic glutamate receptor signaling p... (TAS)
0006605 protein targeting (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/428933487.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The EVH1 (WH1.anBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signaling.uclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role incytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity.urther interactions then form between flanking residues WASP family proteins contain a EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N terminal region.hich seems to bind a different sequence motif present in the C terminalpart of RanGTP protein . Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin homology (PH) domain. The overall fold consists of a compact parallel beta-sandwich.losed along one edge by a long alpha-helix. A highlyconserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecules target ligands. .
  IPR000697:EVH1
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling proteins.here they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C delta-1.eta-spectrin.ynamin.on-of-sevenless.rp1.nc-89.app1 and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
IPR000697:WH1 
Evalue:-55.0043640136719 
Location:6-110
SequencesProtein: HOME3_HUMAN (361 aa)
mRNA: AF093265 NM_004838
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 142 residues, 18901011-18901434Exon2: 31 residues, 18903133-18903220Exon3: 41 residues, 18903317-18903434Exon4: 54 residues, 18903784-18903941Exon5: 41 residues, 18904732-18904851Exon6: 39 residues, 18906108-18906219Exon7: 46 residues, 18910161-18910293Exon8: 54 residues, 18910536-18910693Exon9: 29 residues, 18910777-18910858Exon10: 7 residues, 18912129-18912145Exon11: 2 residues, -Jump to HOME3_HUMANExon1: 145 residues, 18901011-18901443Exon2: 31 residues, 18903133-18903220Exon3: 41 residues, 18903317-18903434Exon4: 54 residues, 18903784-18903941Exon5: 42 residues, 18904732-18904854Exon6: 38 residues, 18906111-18906219Exon7: 46 residues, 18910161-18910293Exon8: 54 residues, 18910536-18910693Exon9: 29 residues, 18910777-18910858Exon10: 43 residues, 18912859-18912983Exon11: 2 residues, -Jump to HOME3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4381 18754582-18763114 ~-9K 18371(COMP)(-)Loci: 3100 18803787-18840038 ~-36K 18373(RENT1)(+)Loci: 4382 18871323-18891199 ~-20K 18381(COPE)(-)Loci: 4383 18901011-18912983 ~-12K 18385(HOMER3)(-)Loci: 3101 19035807-19084697 ~-49K 18393(+)Loci: 3099 18655487-18749762 ~-94K 18368(MECT1)(+)Link out to UCSC