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0HOME2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionHomer protein homolog 2 (homer-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0007216 metabotropic glutamate receptor signaling p... (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The EVH1 (WH1.anBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signaling.uclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role incytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity.urther interactions then form between flanking residues WASP family proteins contain a EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N terminal region.hich seems to bind a different sequence motif present in the C terminalpart of RanGTP protein . Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin homology (PH) domain. The overall fold consists of a compact parallel beta-sandwich.losed along one edge by a long alpha-helix. A highlyconserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecules target ligands. .
Pleckstrin homology (PH) domains are small modular domains that occur once.r occasionally several times.n a large variety of signalling they serve as simple targeting domains that recognize only phosphoinositide headgroups . PH domains can target their host protein to the plasma and internal membranes through its association with phosphoinositides. PH domains have a partly opened beta-barrel topology that is capped by an alpha helix. Proteins containing PH domains include pleckstrin (N-terminal).hospholipase C and Rac-alpha kinase.The structure of PH domains is similar to the phosphotyrosine-binding domain (PTB) found in IRS-1 (insulin receptor substrate 1).hc adaptor and Numb; to the Ran-binding domain.ound in Nup nuclear pore complex and Ranbp1; to the Enabled/VASP homology domain 1 (EVH1 domain).ound in Enabled.ASP (vasodilator-stimulated phosphoprotein).omer and WASP actin regulatory protein; to the third domain of FERM.ound in moesin.adixin.zrin.erlin and talin; and to the PH-like domain of neurobeachin.
  IPR011993:Pleckstrin homology-type
SequencesProtein: HOME2_HUMAN (354 aa)
mRNA: NM_199330
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 307 residues, 81314791-81315709Exon2: 29 residues, 81316956-81317037Exon3: 39 residues, 81317947-81318058Exon4: 54 residues, 81320449-81320606Exon5: 48 residues, 81324834-81324974Exon6: 33 residues, 81329972-81330065Exon7: 46 residues, 81341078-81341210Exon8: 54 residues, 81352440-81352597Exon9: 65 residues, 81412286-81412477Exon10: 2 residues, -Jump to HOME2_HUMAN  
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Loci Cluster (Details)Loci: 4188 81715658-81744472 ~-29K 12914(BNC1)(-)Loci: 2904 81907145-82078495 ~-171K 12915(SH3GL3)(+)Loci: 4187 81314791-81412477 ~-98K 12904(HOMER2)(-)Link out to UCSC