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0HNRLL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHNRPLL
DescriptionHeterogeneous nuclear ribonucleoprotein l-like (stromal rna regulating factor) (block24 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Many eukaryotic proteins that are known or supposed to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids. This is known as the eukaryotic putative RNA-binding region RNP-1 signature or RNA recognition motif (RRM). RRMs are found in a variety of RNA binding proteins.ncluding heterogeneous nuclear ribonucleoproteins (hnRNPs).roteins implicated in regulation of alternative splicing.nd protein components of small nuclear ribonucleoproteins (snRNPs). The RRM in heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) appears to have two RRM-like domains with specialized features for protein recognition . The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich.ith a third helix present during RNA binding in some cases .
  IPR000504:RNA-binding region RNP-1 (RNA recognition motif)
Included in this family of heterogeneous ribonucleoproteins are PTB (polypyrimidine tract binding protein ) and hnRNP-L . These proteins contain four RNA recognition motifs.
  IPR006536:HnRNP-L/PTB/hephaestus splicing factor
This entry represents nucleotide-binding domains with an alpha-beta plait structure.hich consists of either a ferredoxin-like (beta-alpha-beta)2 fold.uch as that found in RNA-binding domains of various ribonucleoproteins or in viral DNA-binding domains . or a beta-(alpha)-beta-alpha-beta(2) fold.uch as that found in the ribosomal protein L23 .
  IPR012677:Nucleotide-binding, alpha-beta plait
IPR000504:RRM 
Evalue:-6.85387196432176 
Location:336-405IPR000504:RRM_1 
Evalue:-5.32790231704712 
Location:78-128IPR000504:RRM 
Evalue:-1.88605664769316 
Location:167-240IPR012677:Nucl_bd_a/b_plat 
Evalue:0 
Location:451-522IPR000634:DEHYDRATASE_SER_THR 
Evalue:0 
Location:419-432
SequencesProtein: HNRLL_HUMAN (542 aa)
mRNA: NM_138394
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 68 residues, 38644680-38644883Exon2: 35 residues, 38648844-38648943Exon3: 21 residues, 38649031-38649089Exon4: 69 residues, 38649778-38649980Exon5: 42 residues, 38650449-38650571Exon6: 74 residues, 38653855-38654073Exon7: 26 residues, 38658106-38658178Exon8: 26 residues, 38662558-38662631Exon9: 34 residues, 38662717-38662814Exon10: 30 residues, 38664486-38664572Exon11: 81 residues, 38666289-38666527Exon12: 41 residues, 38672175-38672294Exon13: 150 residues, 38683083-38683528Exon14: 2 residues, -Jump to HNRLL_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4435 38824248-38832005 ~-8K 20300(SFRS7)(-)Loci: 4434 38644680-38683528 ~-39K 20297(HNRPLL)(-)Link out to UCSC