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0HMOX1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHMOX1
DescriptionHeme oxygenase 1 (ec 1.14.99.3) (ho-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005624 membrane fraction (TAS)
0004392 heme oxygenase (decyclizing) activity (TAS)
0004871 signal transducer activity (IMP)
0043123 positive regulation of I-kappaB kinase/NF-k... (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
Haem oxygenase () (HO) is the microsomal enzyme that.n animals.arries out the oxidation of haem.t cleaves the haem ring at the alpha-methene bridge to form biliverdin and carbon monoxide . Biliverdin is subsequently converted to bilirubin by biliverdin reductase. In mammals there are three isozymes of haem oxygenase: HO-1 to HO-3. The first two isozymes differ in their tissue expression and their inducibility: HO-1 is highly inducible by its substrate haem and by various non-haem substances.hile HO-2 is non-inducible. It has been suggested that HO-2 could be implicated in the production of carbon monoxide in the brain where it is said to act as a neurotransmitter. In the genome of the chloroplast of red algae as well as in cyanobacteria.here is a haem oxygenase (gene pbsA) that is the key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae . A haem oxygenase is also present in the bacteria Corynebacterium diphtheriae (gene hmuO).here it is involved in the acquisition of iron from the host haem . There is.n the central section of these enzymes. well-conserved region centred on a histidine residue.
  IPR002051:Haem oxygenase
IPR002051:Heme_oxygenase 
Evalue:-126 
Location:11-216
SequencesProtein: HMOX1_HUMAN (288 aa)
mRNA: NM_002133
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:domains)
KO assignmentK00510
  Level 3 annotation:
    heme oxygenase
  Level 2 annotation:
    Porphyrin and chlorophyll metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 35 residues, 34107086-34107189Exon2: 42 residues, 34109098-34109219Exon3: 166 residues, 34112677-34113169Exon4: 35 residues, 34115856-34115956Exon5: 246 residues, 34119460-34120194Exon6: 2 residues, -Jump to HMOX1_HUMAN  
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Loci Cluster (Details)Loci: 3312 34107086-34120194 ~-13K 24618(HMOX1)(+)Loci: 3311 34025860-34073973 ~-48K 24616(TOM1)(+)Link out to UCSC