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0HIRA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHIRA
DescriptionHira protein (tup1-like enhancer of split protein 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0003714 transcription corepressor activity (TAS)
0003700 transcription factor activity (TAS)
0009653 morphogenesis (TAS)
0006357 regulation of transcription from RNA polyme... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain .
  IPR011494:TUP1-like enhancer of split
WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs.ften terminating in a Trp-Asp (W-D) dipeptide. WD-containing proteins have 4 to 16 repeating units.ll of which are thought to form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. The underlying common function of all WD-repeat proteins is coordinating multi-protein complex assemblies.here the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller).AFII transcription factor.nd E3 ubiquitin ligase .
  IPR001680:WD-40 repeat
IPR011494:Hira 
Evalue:-95.7447280883789 
Location:763-962IPR001680:WD40 
Evalue:-10.2839965820313 
Location:121-159IPR001680:WD40 
Evalue:-7.76955127716064 
Location:60-98IPR001680:WD40 
Evalue:-6.60205984115601 
Location:164-202IPR001680:WD40 
Evalue:-4.408935546875 
Location:258-313IPR001680:WD40 
Evalue:-0.823908740944319 
Location:1-44IPR001680:WD40 
Evalue:0.462397997898956 
Location:319-356IPR001680:WD40 
Evalue:1.96848294855393 
Location:212-254
SequencesProtein: HIRA_HUMAN (1017 aa)
mRNA: NM_003325 X77633
Local Annotation
Synapse Ontology
?
sdb:0265 cAMP mediated STP  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 286 residues, 17698223-17699079Exon2: 31 residues, 17718880-17718969Exon3: 56 residues, 17720878-17721042Exon4: 43 residues, 17721518-17721641Exon5: 37 residues, 17723282-17723388Exon6: 21 residues, 17723752-17723811Exon7: 56 residues, 17724412-17724574Exon8: 51 residues, 17726858-17727007Exon9: 37 residues, 17728759-17728864Exon10: 70 residues, 17729249-17729454Exon11: 56 residues, 17743153-17743315Exon12: 68 residues, 17745391-17745589Exon13: 30 residues, 17751142-17751228Exon14: 74 residues, 17753043-17753259Exon15: 37 residues, 17755233-17755339Exon16: 25 residues, 17756006-17756077Exon17: 40 residues, 17759623-17759737Exon18: 58 residues, 17761864-17762032Exon19: 55 residues, 17764309-17764470Exon20: 34 residues, 17765514-17765610Exon21: 33 residues, 17773308-17773403Exon22: 32 residues, 17774706-17774797Exon23: 39 residues, 17776005-17776116Exon24: 23 residues, 17778238-17778301Exon25: 87 residues, 17798962-17799219Exon26: 2 residues, -Jump to HIRA_HUMANExon1: 170 residues, 17698571-17699079Exon2: 31 residues, 17718880-17718969Exon3: 56 residues, 17720878-17721042Exon4: 43 residues, 17721518-17721641Exon5: 37 residues, 17723282-17723388Exon6: 21 residues, 17723752-17723811Exon7: 56 residues, 17724412-17724574Exon8: 51 residues, 17726858-17727007Exon9: 37 residues, 17728759-17728864Exon10: 70 residues, 17729249-17729454Exon11: 56 residues, 17743153-17743315Exon12: 68 residues, 17745391-17745589Exon13: 30 residues, 17751142-17751228Exon14: 74 residues, 17753043-17753259Exon15: 37 residues, 17755233-17755339Exon16: 25 residues, 17756006-17756077Exon17: 40 residues, 17759623-17759737Exon18: 58 residues, 17761864-17762032Exon19: 55 residues, 17764309-17764470Exon20: 34 residues, 17765514-17765610Exon21: 33 residues, 17773308-17773403Exon22: 32 residues, 17774706-17774797Exon23: 39 residues, 17776005-17776116Exon24: 23 residues, 17778238-17778302Exon25: 2 residues, -Jump to HIRA_HUMAN  
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Loci Cluster (Details)Loci: 4555 16596905-16637258 ~-40K 24143(BID)(-)Loci: 3295 16973558-16994498 ~-21K 24153(TUBA8)(+)Loci: 4556 17280294-17304066 ~-24K 24158(PRODH)(-)Loci: 4557 17543094-17546285 ~-3K 24164(SLC25A1)(-)Loci: 4558 17698223-17799219 ~-101K 24167(HIRA)(-)Loci: 3296 18081986-18090842 ~-9K 24176(SEPT5)(+)Loci: 4559 18243045-18309515 ~-66K 24188(TXNRD2)(-)Loci: 3297 18309308-18336528 ~-27K 24191(COMT)(+)Loci: 3294 16423182-16453647 ~-30K 24138(SLC25A18)(+)Link out to UCSC